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Continuous monitoring of ventilation with the Hexoskin smart shirt to detect dynamic hyperinflation in COPD patients

The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…

Manipulation under anaesthesia versus conservative treatment in phase 2 of a frozen shoulder: a randomized controlled trial

Primary Objective: The primary objective of this study is to evaluate the difference in functional outcome, measured by the SPADI, after treatment of a frozen shoulder with or without manipulation under anaesthesia. Primary outcome parameter:…

A PHASE 2, RANDOMIZED, VEHICLE-CONTROLLED, DOUBLE-BLIND, PARALLEL-GROUP STUDY TO EXPLORE THE PHARMACODYNAMICS, SAFETY AND EFFICACY OF TOPICAL OMIGANAN IN PATIENTS WITH EXTERNAL GENITAL WARTS.

Primary Objectives* To explore the pharmacodynamic effects of topically applied omiganan in patients with external genital warts* To explore clinical efficacy of omiganan compared to placebo in patients with external genital warts.Secondary…

NEUROcognitive fitness: Studying changes in Hippocampal Adult neurogenesis and cognition induced by Physical Exercise

Primary objective:- To investigate if exercise can modulate neurogenesis and angiogenesis in vivo, and whether this is associated with changes in hippocampal function, such as pattern separationSecondary objectives:- To assess whether exercise-…

Improving quality of survivorship for breast cancer-related lymphedema by lymphatic microsurgery: A randomized controlled trial

To assess the effectivity of LVA on arm volume in comparison to standard therapy after 12 months.

Corrective osteotomy of the distal radius: evaluation of a patient-tailored positioning and fixation plate.

To investigate clinical outcome, functional outcome and accuracy of patient-tailored plating in corrective osteotomy procedures and compare this to the standard osteotomy procedures based on 2D imaging and standard fixation plates. Additionally we…

A randomized, double-blind, two-way crossover study to compare the pharmacokinetics, pharmacodynamics and safety of a single subcutaneous administration of LA-EP2006 and a single subcutaneous administration of Neulasta® (EU-authorized) in healthy subjects

The purpose of the study is to compare LA-EP2006 and Neulasta® with respect to how quickly and to what extent the compounds are absorbed and eliminated from the body after injection under the skin of the abdomen (this is called pharmacokinetics). It…

Peri-operative unobtrusive core temperature measurement - clinical pilot trial

Compare the performance of an unobtrusive new medical device with a CE-marked esophageal and/or rectal reference sensor (Covedien Mon-a-Therm, General Purpose Temperature Probe 400TM) for core body temperature in patients undergoing surgery in which…

A dual stable isotope method to assess dietary protein quality in humans:
Characterization of intrinsically labelled 15N milk protein as a reference protein

The present project characterizes the use of 15N-intrinsically-labelled milk protein as a reference-protein for development a minimal invasive method that can be used to assess protein quality in human subjects. For this purpose, our primary…

Measurement of local arterial stiffness in the carotid artery in subjects at low and high cardiovascular risk and in patients with recent ischaemic cerebrovascular events.

The main goal of this study is to assess the difference in local pulse wave velocity measured at three different points in the left and right carotid artery in healthy subjects and in patients with symptomatic and asymptomatic carotid plaques. As…

Implementing Treatment Algorithms for the Cure of Trauma Induced Coagulopathy (iTACTIC)

The primary objective is to compare the haemostatic effect of VHA-guided transfusion strategy versus optimized CCT guided transfusion strategy in haemorrhaging trauma patients. The secondary objectives of the study are to determine the effects of…

Effectiveness of Percutane Tibiale Nerve Stimulation (PTNS) treatment in children

The goal of this study is to analyse the effect and safety of PTNS in 20 children with persistent overactive bladder complaints refractory to standard treatment

Early phase development of anti-drug-antibodies in rheumatoid arthritis patients

PRIMARY OBJECTIVETo identify the cellular mechanism behind early antidrug antibody (ADAb) production related to humoral responses within first 3 months of BP treatment.SECONDARY OBJECTIVES- To identify the affinity maturation process in ADAb…

Pruritus and pemphigoid in nursing home patients

To determine the prevalence of pruritus and pemphigoid in nursing home patients.To assess the relationship of demographic and medical risk factors with pemphigoid in nursing home patients.To assess the association between pruritus and…

PreventIT adapted Lifestyle-integrated Functional Exercise Program Pilot study

To evaluate the feasibility and acceptability of the adapted Lifestyle-integrated Functional Exercise Program (aLiFE) intervention in a population of young old adults (60-70 years) at three sites: Stuttgart, Amsterdam, and Trondheim.

Improved screening of esophageal cancer by optical detection of field cancerization.

1. Evaluate the feasibility of ESS for detection of field cancerization in BE patients. 2. Investigate the biological background of field cancerization by studying: a) (ultra)structural changes in the tissue and b) genetic abnormalities and clonal…

EMDR and stalking: a multiple baseline trail on reducing the urge to stalk

The objective of this study is primarily to answer the question if the EMDR Feeling State Addiction Protocol van Miller (2010), can contribute in reducing the urge to stalk. Participating clients are in treatment at De Waag (a out patient forensic…

Towards personalized dosing of natalizumab in multiple sclerosis

Our main objective is to prove that extending dose intervals guided by serum concentrations of natalizumab, will not result in radiological or clinical disease activity.

Cross-sectional characterisation of elderly using the NeuroCart.

Main objectives:To determine differences in NeuroCart profiles in different sub-groups based on cognitive testing and CSF biomarker profiling (i.e. cognitively normal, pre-symptomatic AD, prodromal AD, MCI, mild AD).To characterize a cohort of…

Some control values for MR biomarkers of fatty infiltration and edema-like lesions in skeletal muscles of healthy volunteers - an explorative study

To obtain some control values for the MRI biomarkers for fatty infiltration and edema-like lesions in skeletal muscles of healthy volunteers.