2423 results
a. By this research a treatment protocol for NET will be quantitatively and qualitatively evaluated on its effects. b. With the research findings it is possible to identify subgroups within the research population and indicate who benefits most from…
Primary objective(s):To evaluate the effect of early haloperidol prophylaxis on the incidence, severity and duration of in-hospital delirium in at-risk patients aged 70 years and over who are acutely admitted to the hospital through the ED, for…
Objective: The primary aim of the present study is to investigate the effectiveness of MBCT in a group format versus TAU in a group format for treatment refractory anxiety disorders Furthermore; we will investigate mediators associated with…
Can this effect be utilised clinically, especially in patients with major depressive disorder?
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
Our primary aim is to conduct a large-scale study that investigates the impact of a specialized alliance training and evaluates the effect of the alliance training on the treatment process and outcome. Our secondary aim is to learn more about the…
The primary objective of this study is to provide access to SPD503 following participation in SPD503-315 or SPD503-316. The primary outcome of this study is to evaluate the long-term safety of SPD503. The evaluation of safety will be based on the…
Primary Objectives1. The primary objective of Study 1 is to evaluate the relationship of IPV and children*s symptoms and adjustment within a clinical sample of 75 families exposed to IPV and 50 comparison families, and to test whether this…
The aim of this study is to examine the effectiveness of the IMR program compared to care as usual (CAU) in patients with SMI.
ObjectiveTo investigate the effectiveness of autonomygroups for (Dutch) patients with anxiety disorders.Research questions(1) *Do patients with anxiety disorders show a significant increase of autonomy after the autonomygroup?*(2) *Do patients with…
The objective of the study is to examine characteristics in brain function, structure, hormonal response, genetic makeup and heart rate variability specific for resilience to stress
Our primary objective is to investigate the development of structural and functional connectivity in autism and ADHD in comparison to the typical development of connectivity. A secondary objective is to investigate the effects of ADHD and autism…
The primary objective is to evaluate the efficacy of Namisol® in the management of behavioural disturbances in patients with dementia. Secondary objectives are:- To evaluate the efficacy of Namisol® on secondary outcome measures, such as quality of…
If normal doubt occurs, will OCD patients differ from non-OCD anxiety patients and healthy controls in how much uncertainty they will experience and will OCD patients respond to this with more perseveration (chekcing behavior) than non-OCD anxiety…
The primary aim of the proposed study is to investigate whether adjunctive treatment of negative self-image with a specific intervention module (i.e. COMET) has added value in the treatment of patients with BPD compared with MBT without such a…
This study investigates if the BeweegKuur Depressive Symptoms is more (cost-)effective in comparison with "watchful waiting". Complementary, success factors and barriers of the implementation of the BeweegKuur Depressive Symptoms in…
To establish the effect of an adapted form of MCT (MCT-a) on paranoid ideation and cognitive insight in patients with recent onset psychotic symptoms.
The two primary objectives are to test the hypothesis that (1) structural and functional abnormalities of the fronto-striatal circuits are related to the development of compulsive and impulsive behaviour in ASD and OCD; and that (2) the glutamate…
The main objective of this pilot study is twofold: 1) To investigate whether and to what extent raped adolescents experience symptoms of posttraumatic stress disorder at maximum 18 months of follow-up, measured by standardised questionnaires and…