5130 results
Primary Objective:- To provide continued access to atezolizumab based therapy and/or comparator agent(s) for eligible patients still on study treatment at the time of the parent study closure.Secondary Objectives:- Safety Objective: To evaluate the…
The main objective of the present study is to determine the role of dopamine and stress in functional connectivity in neural substrates for habitual- and goal-directed behaviour and their effects in subsequent behaviour.
The objective of this project is to evaluate the effect of SuperFIT on BMI and several related healthy behaviours. Further, a process evaluation of the development and implementation of SuperFIT will be performed.
Primary Objectives: 1) to investigate whether the neural responses during acquisition and extinction of cue-reward associations differ between obese and normal weight individuals; 2) to investigate whether the neural correlates of self-control in…
Primary objective is to gain insight into risk acceptation of serious adverse events (<30 days) in bariatric surgery. Secondary objectives are the expected weight loss, risk acceptation of mortality, risk acceptation of serious adverse events…
Primary Objective: To compare the composition and functionality of neonatal microbiome arising from mothers receiving antibiotic prophylaxis before skin incision with the microbiome of neonates born when antibiotics are given after umbilical cord…
In patients with neoadjuvant disease the purpose of the study is to define the safety and tolerability of the drug. In patients with metastatic disease the purpose is to determine if treatment with Nivolumab or Nivolumab and ipilimumab will lead to…
Primary ObjectivesDose Escalation Phase* To determine the maximum tolerated dose (MTD) of multiple ERY974 dosing schedules, including fixed dose schedules and an individual dose titration schedule, in patients with locally advanced or metastatic…
The aim of this study is to assess differences in the endogenous pain modulation paradigm in older and younger subjects, with and without an intensified sports regimen (ie. oarsmen).
The aim of this study is to examine the effectiveness of a nurse-coordinated Cardiac Care Bridge program consisting of care coordination, cardiovascular risk management and home-based rehabilitation for high-risk cardiac patients of 70 years and…
This study will investigate whether treatment with Nivolumab in combination with radiation therapy, is comparable to Temozolomide in combination with radiation therapy in patients with Unmethylated MGMT Glioblastoma. We will measure this by…
To investigate whether a tailored physical activity program that starts early (during curative chemotherapy with cardiovascular toxic potential) is superior in terms of reducing long-term cancer-treatment-related metabolic syndrome and…
Primary objective: Is there a difference in the change in perfused vessel density between obese and lean subjects after cardiac surgery with cardiopulmonary bypass?Secondary Objectives * Is there a difference in baseline perfused vessel density…
(1) To examine whether the exposure to BWL yields clinically significant reductions in CRF compared to exposure to dim white light in (non-)Hodgkin survivors. (2) To examine the effect of exposure to BWL compared to DWL on sleep quality and…
1. To investigate the feasibility of web-based cognitive CBT among severely fatigued adolescent patients with an immune dysregulation disorder, and 2. To estimate intervention effects on reducing fatigue, associated chronic pain and fatigue related…
Objectives for Part A1 Monotherapy Dose EscalationPrimary Objective:* To assess safety, and tolerability at increasing dose levels of PF 04518600 in patients with selected advanced or metastatic solid tumors in order to establish the MTD.Secondary…
The main goal of the study is to assess the incidence of respiratory events using the IPI device.
To develop a population pharmacokinetic model of Envarsus in stable liver transplant recipients and to evaluate the effect of CYP3A5*3, CYP3A4*22 and IL-polymorphisms of both donor and recipient on Envarsus pharmacokinetics for initial dose…
The goal of this project is to elucidate the relation between structural differences in the brain and cognitive performance in younger and elderly participants. By utilizing the strength of high spatial resolution MRI we will compute measures of…
A) To investigate the pharmacokinetics and determinants of MTX-PG accumulation in plasma and erythrocytes in adult CNS lymphoma and leukemia patients treated with HD-MTX;B) To investigate whether intracellular MTX levels are related to toxicity in…