232 results
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presentingwith Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation utilizing the…
The primary objective of the study is to compare the progression-free survival (PFS) of REGN2810 (cemiplimab) plus ipilimumab combination therapy (hereinafter referred to as REGN2810/ipi) and REGN2810 plus 2 cycles only of platinum-based doublet…
The effect of body composition on the farmacokinetiek IFX in patients with inflammtoy bowel disease;
The aim of the studie is to determine the correlation between fat mass end the IFX concentration. Primary research question:What is the effect of fat mass percentage, measured by a validated scale, and secundaire skinfold measurement, waist…
To compare event-free survival (EFS) of the experimental treatment arm including ATO/ATRA and idarubicin with standard treatment based on ATRA plus chemotherapy (AIDA regimen).
Primary Objective: To investigate, in a series of studies, what effect the elements of CBT for tinnitus have on tinnitus distress. Study 1: The objective of study 1 is to examine the effects of audiological assessment, psychological assessment and a…
The objective of the study is to determine hypothalamic function in response to oral glucose ingestion in obese subjects.
To investigate the effects of in-phase and anti-phase bilateral frontal theta tACS (5 Hz) on gambling behaviour and endogenous frontal theta activity.
The main objective of this prospective randomized study is to examine the effect of low-dose radiotherapy on pain sensation in patients with early OA of the hip. Our hypothesis is that radiotherapy can achieve a pain-reducing effect of at least 20%…
Research proposalTo find out what is the best surgical procedure for patients with conservative therapy resistent calcifying tendinitis of the shoulder. Objectives Our main objective is to compare the three different surgical procedures for the…
The objective of this study is to investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as identified in epigenome-wide…
The main goal of the study is to measure the effectiveness of the Patient and Partner Education program 4 all (PPEP4ALL) in patients with hypoxic brain injury and/or their spouse/caregiver.
Primary research questions:1. Does tinnitusspecific- behavioural exposure-treatment (T-BET) decrease tinnitus-related fear, tinnitus-severity and enhance recovery, when compared to a masking-therapy with use of personalised on-ear masking-devices,…
The study comprises 2 parts.Part 1: Primary: to assess sexual functioning, sexual self image and psychological and relational functioning in MRKH women with surgical or non- surgical created neovaginas and their partners and make a comparison with…
Safety and electrical performance evaluation of Invicta leads moodels equipped with DF-4-connector.Clinical study to support the submission for acquiring the CE-mark.
This study has multiple purposes:Primary objective:1: to investigate whether it is possible to identify the small mimic muscles independently of each other and to determine the exact position of the mimic muscles from origin to insertion on MRI…
Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…
To screen two different formulations of the recombinant malaria vaccine PfLSA-3-rec, one adjuvated with aluminium hydroxide and one with Montanide Isa 720, by assessing the safety and immunogenicity (phase I) profile of each formulation in humans,…
Accurate MR-HIFU ablation of liver metastases is feasible
The primary objective is to determine the feasibility of applying CPC-PLGA in sinus floor elevation surgery in terms of bone formation and implant survival. The secondary objective is to investigate pain, health-related quality of life and the…
The primary research question is:-What is the influence of cognitive functioning on on the quality of life after SAH on the long term?Two secundary research questions are:-Is there a specific neuropsychological profile after SAH on the long term?-…