1803 results
1. To identify and specify bacteria by using RT-PCR on blood and cerebrospinal fluid (CSF) in preterm infants, having nosocomial sepsis and meningitis.2. To compare RT-PCR (see aim 1) with the gold standard bacterial culture in preterm infants,…
To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…
The present study is designed to test the hypothesis that new imaging modalities like PET with the use of HED and contrast enhanced CMR to quantify fibrosis size and heterogeneity of scar tissue can give a further risk stratification for ventricular…
To document the long-term safety and tolerability of teriflunomide in MS patients with relapses.
This study aims at developing a novel strategy to optimise the treatment of oesophageal adenocarcinoma and gastro-oesophageal junctional tumors with curative intent. To improve the outcome of patients with this disease we hypothesize that the…
1. To determine the diagnostic accuracy, in terms of detecting a vascular malformation, of CTA, MRI/MRA, DSA, or combinations thereof in patients with ICH?2. To find out which test or combination of tests is most effective for the detection of…
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
The purpose of this study in patients with primary progressive multiple sclerosis (PPMS) is to evaluatewhether FTY720 is effective in delaying MS disability progression in the absence of relapsescompared to placebo. Furthermore, safety and…
A. Determine the placement of the Maple-probe in relation to the anatomy of the pelvic floor musculature.B. Determine the normal rest tone of the pelvic floor musculatureC. Determine the normal activity of the pelvic floor musculatureD. Determine…
The objective of this study is to establish the (cost) effectiveness of transmural collaborative care including a Consultation Letter for the GP and duloxetine (TCCCL) versus Duloxetine in patients with depression that present themselves with (sub)…
To demonstrate whether using MSCT to reclassify individuals who are at high-risk based on traditional risk factors.
The current study seeks to explore the SDOCT potential in a large group of patients in a clinical setting, and to compare it to existing, standard techniques.
Objective: Primary Objective is to evaluate implant stability of the TMC prosthesis. Secondary Objectives are to monitor improvement of function, pain scores and long term survivalship after TMC prosthesis implantation.
Evaluation of acute joint damage immediately after a joint bleed in patients with haemophilia, by use of a panel of state-of-the-art biomarkers of cartilage and bone turnover measured in blood and urine. The question that will be addressed is…
To assess the difference in treatment effect (change between start and 6, 12, 54 and 78 months follow-up of fatigue severity and quality of life in patients with chronic fatigue syndrome) between individual multidisciplinary rehabilitation treatment…
Aim of this prospective study is to determine (temporal changes in) the intestinal microbiota in faecal specimens and microbiota adhering to the intestinal mucosa using bacterial DNA-based profiling methods.
To assess the long-term safety and tolerability of macitentan in patients with symptomatic pulmonary arterial hypertension (PAH).
To define indications for recently developed, but more expensive, self-expanding metal stents (SEMS) versus cheaper plastic stents in patients with primary or recurrent inoperable malignant extrahepatic common bile duct (CBD) obstruction, based on…
At CHDR, experience has been gained with the assessment of the in vitro inhibition by MAP kinases of the LPS-induced TNFα release in healthy male volunteers. However, relatively little is known on the inhibition by MAP-kinases in other populations.…
The purpose of this study is to determine the need for thromboprofylaxis in patients being treated in a below-knee plaster cast after trauma of a lower extremity and if there is, to assess if both of the two tested prophylactic treatments are suited…