663 results
Primary objective is to gain insight into risk acceptation of serious adverse events (<30 days) in bariatric surgery. Secondary objectives are the expected weight loss, risk acceptation of mortality, risk acceptation of serious adverse events…
To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.
The aim of this study is to examine the effectiveness of a nurse-coordinated Cardiac Care Bridge program consisting of care coordination, cardiovascular risk management and home-based rehabilitation for high-risk cardiac patients of 70 years and…
Objectives.The primary aims of this multicenter randomized clinical trial (RCT) are threefold1. to investigate whether a structured assessment and treatment program of intensive, supervised pre-partum pelvic floor muscle group training (PFMGT)…
The objective of this study:The overarching object of this study is to assess if the three tests for physical functioning ('together ASPI measurement') are reliable for patients with (early or suspicion of) axial spondyloarthritis and to…
The aim of this study is to guide European PH-centers to become specialized centers for training in PH. This approach is in line with European PH-guidelines [12] which classified the exercise training in specialized centers with a closely monitored…
1. Inventory of the current care of boys/men with Duchenne Muscular Dystrophy in the Netherlands: To establish the extent of implementation of the international guidelines and its updates in the Netherlands and to explore the relationship between…
To examine the goals of patients and doctors for treatment with chemotherapy, immunotherapy or targeted therapy in metastatic lung cancer and whether these goals are achieved according to patients, doctors and relatives.
In the MILESTONE study, we will test and evaluate a model of managed transition which contains a planned, purposeful and needsbasedassessment of those who reach the transition boundary at CAMHS. The Transition Readiness and Appropriateness Measure…
The primary objective is to assess how training, acutely and chronically, influences gene expression patterns in different individuals.Gene expression values of samples taken around an exercise performance test will be used to assess the acute…
Objective: The main objective of this study is to explore the executive, social-cognitive, and social functioning and behaviour of HT1 patients in relation to present and past tyrosine and phenylalanine levels, history of treatment and treatment…
We hypothesise that treatment with nivolumab will extend disease-free survival, compared with placebo, as adjuvant therapy in all randomized patients and in patients with PD-L1 expressing tumours (membranous staining in > 1%) who are at high…
To test telemonitoring with wireless CTG and blood pressure devices as a novel obstetric care strategy compared to hospital admittance in high risk pregnancies who require daily monitoring. Primary outcome is safety of pregnancy outcome measured by…
Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) Study: a randomized clinical trial
Primary Objective: - To investigate whether a 12-week exercise intervention increases HRQoL in patients after curatively intended EC surgery compared to a usual care control group.Secondary Objective(s): - To investigate whether a 12-week exercise…
To evaluate the effects of a tailored invention focused on disease acceptance for patients with haemophilia on prophylaxis.Secondary objectives:* Evaluation of feasibility of collection of preliminary outcomes:o Adherence, measured with the Delphi…
Primary objective of the study is to evaluate whether using the Voeding Slim Thuis (VST) concept can improve food intake and meal satisfaction in vulnerable community-dwelling older adults. The VST concept comprises tailored dietary advice, a…
To demonstrate whether hydrochlorothiazide or metformin can diminish aquaresis in patients with ADPKD who are treated with tolvaptan as measured by 24-hour urine volume.
The primary objective of this research is to obtain insight in de (cost-)efficiency of a multidisciplinary intervention focused on the improvement of return to work after sick leave of employees with cancer. Specific research questions are:- Does…
To evaluate the benefits, risks and costs of laparoscopic gastrectomy as an alternative to open gastrectomy (gold standard) as treatment for gastric cancer in a Western population.
to safely reduce antibiotic prescription by a clinical decision rule in febrile children suspected of CAP