3809 results
To identify risk factors for injuries in novice runners, and to identify risk factors for specific injuries.Secondary Objective(s): 1. To determine the incidence of running related injuries in novice runners2. To describe the health benefits of the…
The main objective of the study is to document cardiovascular dysfunction found in rheumatoid arthritis and gout patients using cardiac imaging techniques echocardiography and cardiac MRI.
Identification of the proteins that are involved in neurite outgrowth in PDR. We want to determine what protein levels are increased in the vitreous by local production and which RNA transcripts are present in the fibrotic membranes of patients with…
Primary objectivesTo quantify coronary artery disease, determined by minimal invasive imaging techniques, as a cause of post-operative myocardial injury in patients undergoing non-cardiac surgery.Secondary objectiveTo correlate coronary calciumscore…
The objectives of this study are to investigate: - which strategies patients use to maintain gait stability and gait adaptability; - whether the strategies used by patients to maintain gait stability and gait adaptability, differ from strategies…
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…
Primary Objective: What are the consequences of irradiation for the human jaw bone and oral mucosa on a macroscopic, microscopic and molecular level?Can possible prognostic factors be identified for the occurrence of peri-implantitis, dental implant…
The principal aim of this project is to identify genetic biomarkers involved in susceptibility for drug-induced liver injury in a set of candidate genes (genes relevant to metabolism of drugs and immune system genes).The results of this study will…
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
PROVALID will have 3 major objectives:Primary: Determine the cumulative incidence of renal outcomes in patients with type II diabetes in different European countries. Renal outcomes are defined as:* Progression from normoalbuminuria to…
The main aim of the present study is to improve our understanding of the role of blood-brain barrier function and cerebral perfusion in dementia of the Alzheimer*s type.
The primary aim of this observational study is to determine the occurrence of exercise-induced left ventricular diastolic dysfunction (LV-DD) in symptomatic COPD patients with a normal echocardiography at rest. And, secondly, to study the…
We try to find a new standard within the field of ''MicroRNA'' proteins, that swim around in peoples blood and/or urine. MicroRNA's are very small proteins, that switches of genes in the cells, they are able to switch genes…
To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis
Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…
Objectives: 1. To investigate the types of antitrombin deficiency in these families2. To find the mutations in our families/patients with antitrombin deficiency.3. To establish the risk of VTE due to these mutations and subtypes.(comparing…
The present study will examine how young-onset-dementia patients and their families can be supported in their home environment as long as possible and institutionalisation can be delayed. For this the functioning and care needs of young-onset-…
Our primary objective is to investigate the development of structural and functional connectivity in autism and ADHD in comparison to the typical development of connectivity. A secondary objective is to investigate the effects of ADHD and autism…
Primary Objective: To study changes of T cell subsets (Th1/Tc1, Th2/Tc2, Th17/Tc17, regulatory T cells and senescent T cells) in healthy ageing and unhealthy ageing. Secondary Objective(s): - To study the immune risk phenotype in healthy persons…