674 results
Pilot study to investigate the influence of pre-treatment with an anti-oxidant solution on the elicitation reaction (the occurrence of an allergic skin reaction after contact with an allergen) in subjects with a proven sensitization to PPD.
To retrieve (in vivo) data about the effect of Staphefekt on the microbiome, including Staphylococcus aureus, and on disease severity in patients with atopic dermatitis.
Objective: The primary objective is to investigate whether sensitive skin fundamentally differs from *normal skin*. In this study, we try to identify the morphological and functional characteristics of sensitive skin by provocation of the skin with…
To develop and validate transplant models of vitiligo and atopic dermatitis for drug testing.
Primary: to evaluate and compare the efficacy of:1) PDL treatment followed by topical sirolimus application after Er:Yag laser ablation of the stratum corneum in PWS 2) PDL treatment followed by topical sirolimus application without Er:Yag laser…
To determine the relationship between phenotypic, genetic and biochemical features of AD. , Relevant bimarkers of the skin barrier function including the levels of NMFs, inflammatory mediators (e.g. IL-1 cytokines), SC lipids and serine proteases…
This study's major aim is to determine whether a relation can be found between specific penile HPV types and the presence, quantity and size of flat penile lesions. Secondly, other possible determinants, such as HIV status, circumcision status…
In this study the material of 20 donors is used to validate the humanized mouse model for psoriasis with clinically relevant compounds.
To assess the preemptive effect of Bepanthen® on decreasing the incidence of specific >= grade 2 dermatological side effects of interest in respect of compliance to EGFRI agents, HRQoL and the adherence during the 6-week skin treatment period…
Primary objective: to evaluate the efficacy of subcutaneous application of methotrexate in patients with moderate to severe Psoriasis compared to Placebo as assessed by achieving the primary endpoint PASI 75 after a 16 week treatment phase.…
Primary Objective: To define a top set of genes that most reliably (r >=0.95) distinguish psoriasis from normal skin. We will define this set from differential methylation genes to indicate potential biomarkers.Secondary Objective(s):…
To assess the efficacy and patient safety of (1)fractional laser treatment in combination with NB- UVB,(2) fractional laser treatment in combination with NB- UVB and topical corticosteroids versus NB-UVB treatment alone.
The objective of this studie is to gather knowledge about cytokine concentrations (IL-1 *) in the skin of healthy volunteers after the application of shear- force. We want to use this knowledge in the future to investigate if different prophylactic…
To test the suitability of OCT for in vivo imaging of the vascularisation and surrounding tissue of burn wounds and scars.
To explore the use of whole exome sequencing in the diagnostic evaluation of patients with epidermolysis bullosa
The objectification of the most effective surgical treatment, in which three operationprocedures are compared.
The main objective of the study is to determine whether induced nocebo effects (negative expectancy effects) for itch can be modified by a positive expectation induction. Secondary objectives are to explore: a) the effects of expectation inductions…
Are Alphabodies against IL23 effecive in the transplant model of psoriasis
The primary research question is:Do children with atopic dermatitis and asthma after a stay in the NAD have a better coping and acceptance of their disease as compared with children treated at the outpatient department of the WKZ?Secondary research…