221 results
Primary objective: determine whether HAPTOS intervention results in earlier attainment (postnatal days) of full enteral feeding and/or full oral feeding (postmenstrual age) compared to standard care. Secondary objectives: To determine whether Haptos…
The aim of this study is to evaluate the AUC, disease status, presence of ADAbs and treatment burden when switching from IV to SC IFX maintenance treatment in a real-world cohort of IBD patients on IFX monotherapy and combination therapy.
1. To gain insights into care needs with regard to death wishes, death thoughts and suicidality of people requesting euthanasia due to psychological suffering;2. To gain insights into characteristics of death wishes, death thoughts and suicidality…
Specific Aim 1) To identify the frequency and risk factors for PVA and its subtypes in ventilated children, with a specific focus on DC breaths. Hypothesis: PVA subtypes related to inadequate ventilator support (flow undershoot and premature cycling…
The primary objective of the study is to examine the effects of group SFT for an out-patient ED population, as assessed by change in both ED pathology as in core self-beliefs. Hypotheses:1. There will be a decrease in dysfunctional core self-beliefs…
The primary objective of this study is to investigate the local tolerability of isoniazid inhalation by wet nebulization at ascending dosages. Secondary objective is systemic pharmacokinetics of inhaled isoniazid compared to intravenous dose…
We aim to confirm that Maastro endoluminal HDR contact brachytherapy boosting is feasible and may increase the chance of functional organ sparing of the rectum in patients with rectal cancer.
This study aims to assess the User experience, Usability and Safety perception of the HEROES exergame in a home environment for people with stroke. This study aims to identify the advantages and disadvantages of the current version of the HEROES of…
The major objective of this clinical investigation is to demonstrate safety and effectiveness of the ablation system (OMNYPULSE* Bi-Directional Catheter and TRUPULSE* Generator) when used for isolation of the atrial PVs in treatment of subjects with…
The primary objective is to execute a feasibility study of the ELFI Health lifestyle intervention for three months in people with prediabetes in primary care (based on HbA1c). The secondary objectives are assessing the impact of the ELFI health…
Primary objective: To compare the exposure of ETI in a group of pwCF with the highest decrease in sweat chlorid and the lowest decrease in sweat chloride as result of ETI therapy.
The aim of the study is to investigate whether SI-NETs can be visualized with indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging (FLI).
In this project, pharmacotherapy will be used to target the molecular basis of memory consolidation in the acute trauma phase to prevent the intrusive aspects of traumatic memories from forming. An excellent candidate to pharmacologically manipulate…
Main objective of this study is to characterize the possible benefits of the new Phonak Marvel CI-CROS device on speech understanding in noise, including its implemented beamformers (UltraZoom and StereoZoom) using different noise setups.
Over the last decades, much fundamental knowledge has been obtained about the neurobiology of antisocial behavior on group level. The main aim of the current study is to translate this group-level knowledge to individualized, developmental profiles…
Hypothesis: implementation of individualized, integrated 7 Tesla MRI and MEG brain networks can increase the effectiveness of DBS by improving motor symptoms and quality of life in patients with Parkinson's disease and essential tremor.…
We aim to lay the fundament of novel interventions by gaining an in-depth comprehensive understanding of individual differences in the overnight adaptation of emotional memory and malleability thereof by noradrenergic modulation.
The primary objective is to evaluate if and to what extend replacing all meat products in an average Dutch diet with currently commercially available PBMAs affects the systolic blood pressure of middle aged men and women in a 2x8 week fully dietary…
Primary objective:1) To determine the discriminating ability of the microvasculature between uteri with adenomyosis, myomas and no uterine disorders. Secondary Objectives: 2) To determine the discriminating ability of the microvasculature between…
The primary objective of this study is to investigate the effect of 26 weeks of supplementation with three different dietary fibres (chicory inulin, resistant dextrin, and seaweed polysaccharide) compared to a placebo (maltodextrin) on microbiota…