1712 results
Primary objectives are:1.1) to study the effect of oral administration of morphine SR on health-related quality of life; 1.2) to explore whether morphine SR leads to respiratory adverse effects in patients with advanced COPD. Secondary objectives…
n.v.t.
- To assess the safety and tolerability of live-attenuated RSV vaccine in healthy adults.- To assess the immunogenicity of the live-attenuated RSV vaccine (systemic and mucosal immunity) - To assess the viral load/shedding of the live-attenuated RSV…
1. To define the optimal pharmacokinetic tracer model for [18F]afatinib. 2. To determine the optimal simplified measure for quantifying tumor [18F]afatinib uptake 3. To assess [18F]afatinib uptake differences between patients (1) with wild type EGFR…
to assess the pulmonary toxicity in patients treated with cyclophosphamide compared to a control group
The aim of the present pilot study is to investigate whether nHFT of different settings (with different flow rates and additional amounts of oxygen) stabilizes respiration and thus improves AHI index and promotes compliance with the therapy in…
The primary objective is to evaluate the antitumor activity of ceritinib in patients with ALK-positive NSCLC metastatic to the brain and/or toleptomeninges based on whole body overall response rate (ORR), defined as the proportion of patients with a…
The objective is to find the most effective combination of wearable devices to accurately reflect paediatric asthma control in a home monitoring situation, by studying the relation of the home-measured signals to the currently used exercise…
Investigating the efficacy and feasibility of working memory training in COPD patients on cognitive performance, cognitive stress susceptibility and perception, self-control / impulse control, and adherence to physical activity and dietary…
The objective of the trial is to assess the efficacy and safety of nintedanib in the treatment ofSSc with ILD at a dose of 150 mg bid compared to placebo.
AIMTo discover the molecular, cellular and structural airway targets of BT and link these to severe asthma phenotypes and outcome.OBJECTIVES1. To identify molecular and cellular targets of BT therapy and related changes in airway remodelling. 2. To…
To identify the characteristics on pCLE and OCT images of the alveolar compartment in mechanically ventilated critically ill patients with non-resolving acute respiratory failure.
The objective of this study is to improve the understanding of subjective cognitive complaints expressed by patients with OSAS by:1. Comparing subjective cognitive complaints of patients with OSAS to healthy controls2. Studying the effect of…
To test the safety and feasibility of a closed loop controller of the FiO2 based on the measured SpO2 in a NICU setting.
* To determine if buprenorphine action at the MOR receptor can inhibit the respiratory depression response to IV fentanyl injection in healthy subjects and patients with chronic opioid use;* To determine if therapeutic concentrations achieved with…
The aim of this study is to guide European PH-centers to become specialized centers for training in PH. This approach is in line with European PH-guidelines [12] which classified the exercise training in specialized centers with a closely monitored…
This study will evaluate the effect of dose tracking in conjunction with reminder notificationsand motivational/adaptive messages over 24 weeks on treatment adherence behavior insubjects with COPD. The dose tracking is done by the Concept2 inhaler…
In this prospective observational cohort study we aim to study the potential clinical consequences of antibiotic use in early life, by focussing on the incidence of eczema, as well as food allergy, upper respiratory tract infections (URTI), lower…
To examine the goals of patients and doctors for treatment with chemotherapy, immunotherapy or targeted therapy in metastatic lung cancer and whether these goals are achieved according to patients, doctors and relatives.
The primary objective of the study is to evaluate the diagnostic accuracy of a CTEPH screening program based on the stratification score and the *rule out criteria*.To prospectively assess the feasibility and cost-effectiveness of the CTEPH…