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A randomised, multicentre, double-blind, placebo-controlled, crossover trial determining the efficacy of dry powder mannitol in improving lung function in subject with Cystic Fibrosis aged six to seventeen years.

The purpose of this trial is primarily to assess the efficacy of inhaled mannitol compared with a true placebo in subjects with cystic fibrosis aged 6 to 17 years.We hypothesize that inhaled mannitol will improve the overall health and hygiene of…

Assessment of real life and trained inhalation of Tobramycin Inhalation Powder (TIP) and Tobramycin Inhalation Solution (TIS) TIPTIS study.

Primary objective of the study is to record TIP inhalations on video at home to study the association between inhalation manoeuver and cough. Secondary objectives are: To study the inhalation maneuvers of patients using TIP in the home situation; to…

Livestock Farming and Neighbouring residents* health: The VGO-study

The generic objective of the study is to explore associations between exposure to livestock farms and potential health effects. This study will focus on 1) respiratory health effects, 2) Livestock associated infections (zoonoses), 3) Carriage of…

eVita COPD; Patient Centered Care through eHealth Solutions

The main aim is to investigate clinical effects of different implementation methods of online supported self-management for COPD patients in primary care. Secondary objectives include effects on well-being, health care use and actual use of the…

Skeletal Muscle Metabolism during Rest, Exercise and Recovery in Patients with Cystic Fibrosis and Healthy Controls

To compare the oxygenation and oxidative metabolism in skeletal muscles of patients with CF with healthy controls to provide insight in the metabolism in patients with CF.

Biomarkers in acute and chronic bacterial endobronchial infections in Cystic Fibrosis
A Pilot study

Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…

A Microdose Study to Describe the Intravenous Pharmacokinetics of [14C]-GSK2239633 in Healthy Male Subjects.

Primary:To investigate the intravenous pharmacokinetics of [14C]-GSK2239633 in healthy male subjectsTo compare total radioactivity (drug-related material) in plasma relative to parent plasma concentrationTo determine total radioactivity (drug-…

Mucoviscidosis and Inflammation, Variability through Exercise and Training: physical exercise program

Primary objective:What is the effect of a 12 weeks physical exercise program on the exercise induced inflammatory response in patients with cystic fibrosis?Secundary objectives:- What are the differences in pre-training basal immune values of…

An Open-Label, Randomized, Phase 3 Trial to Evaluate the Efficacy and Safety of Aztreonam 75 mg Powder and Diluent for Nebuliser Solution (AZLI) versus Tobramycin Nebuliser Solution (TNS) in an Intermittent Aerosolized Antibiotic Regimen, in subjects with Cystic Fibrosis followed by an Open Label, Single Arm Extension

The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…

Lung function and exercise capacity in late preterms

Research of lung function and exercise capacity in late preterms (32-36 weeks gestation) in comparison with term born controls of 8 years

Health effects of sport participation in children and adolescents with a chronic disease or condition.
Sport-2-Stay-Fit (S2SF) study

The Sport-2-Stay-Fit (S2SF) Study will investigate if an after school sports program increase the sustainability of a standardized interval training program in children and adolescents with a physical disability or chronic disease.

Multi-center, randomized, double-blind, placebo-controlled phase 2 study to assess the safety, tolerability and early signs of efficacy of tid orally administered BAY63-2521 in adult deltaF508
homozygous Cystic Fibrosis patients

The aim of this trial is to test in a first clinical study the above mentioned hypothesis that BAY63-2521 can at least partially correct deltaF508-CFTR function. Therefore, we plan to include patients with Cystic Fibrosis, who are homozygous for the…

Assessment of central airways mechanics using Magnetic Resonance Imaging (MRI) and bronchoscopy: a comparison

We hypothesize that the new MRI protocol will be sensitive enough to detect a diagnostic change of >= 50% change from the normal shaped trachea. The primary objective of this study is to determine sensitivity, and specificity, of our MRI…

central airways and lung volume assessment by Magnetic Resonance Imaging in children

Primary objective: to evaluate the image quality between the two protocols using Signal to Noise Ratio (SNR) measurements Secondary objectives: 1) test if measurements of lung volume and central airways dimensions using MRI are related to validated…

Are children with congenital heart or lung disease fit-to-fly?

This study will investigate the feasibility of a hypoxic challaenge test (60 minutes duration). During this test the inspired air will have a oxygen content of 15%. This is a comparable value as is used during a commercial airline flight (ca 2500…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate
the Efficacy and Safety of VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

To evaluate the efficacy of VX-661 in combination with ivacaftor through 24 weeks of treatment in subjects with cystic fibrosis (CF) who are homozygous for the F508del mutation on the CF transmembrane conductance regulator (CFTR) gene.

An exploratory, randomized, double-blind, placebo controlled study to assess the efficacy of multiple doses of omalizumab in cystic fibrosis complicated with allergic bronchopulmonary aspergillosis

A clinical research study to find out if Xolair is safe and has beneficial effects in adolescents (12 years old and above) and adults with cystic fibrosis (CF) and ABPA. All patients entering the study will be taking oral corticosteroids (steroid…

Mucoviscidosis and Inflammation, Variability through Exercise and Training: Maximal exercise test

Primary objective: *What is the effect of an incremental maximal exercise test on inflammation in patients with cystic fibrosis and in healthy people?*Secundary objectives:- What are the differences in basal immune values between HP and CF patients…

Clinical evaluation of a new sweat test system in the diagnosis of cystic fibrosis after newborn screening

To determine the succes rate of the Nanoduct sweat test system.

COPD: Transition of systemic inflammation into multiorgan pathology (study 3).

To investigate in COPD whether: 1. systemic inflammation and multi-organ disease is more pronounced in more severe COPD2. quadriceps oxidative capacity and fiber type I proportion is reduced, and whether age, sex, smoking, physical activity, GOLD…