648 results
To investigate if the use of different stimulation protocols / GnRH-analogues affects embryo developmental kinetics after IVF treatment. We hypothesize that GnRH analogues differentially affect embryo development through differences in follicular…
Primary Objective: * To make a preliminary assessment of the efficacy of a combined APR-246 and carboplatin/PLD chemotherapy regimen in patients with platinum sensitive recurrent HGSOC with mutated p53.Secondary Objective: * To assess the safety…
The primary objective of the study is to assess the incidence of pathological complete response (pCR) in breast and ipsilateral axillary tissue after daily treatment with veliparib in combination with neoadjuvant carboplatin and paclitaxel followed…
Objective procedure 1:To assess the technical feasibility and safety of in-vivo focal imaging with CLE and OCT.Objective procedure 2: Primary Objective: To identify and define characteristics of prostate cancer on CLE and OCT and compare this with…
To be able to assess the value of new markers, we first analyze these potential markers in nipple aspirate fluid and blood from healthy women. The main goal of this study is to evaluate the normal expression levels of microRNAs in NAF and blood to…
Determine the efficacy and safety (using objective response rate) of tremelimumab in patients with advanced solid tumors (UBC, PDAC, TNBC).
To determine which insemination technique in AID (IUI or ICI) is more (cost) effective in terms of ongoing pregnancy leading to a live birth.
The primary objective is to test the hypothesis that endometrial scratching in the cycle preceding controlled ovarian stimulation in women with implantation failure (defined as failure to achieve an ongoing implantation after having completed a full…
The primary objective is to show superiority of treatment with DCVAC/PCa in addition to Standard of Care chemotherapy (docetaxel plus prednisone) over placebo in addition to Standard of Care chemotherapy (docetaxel plus prednisone) in men with mCRPC…
To induce a vaccine specific immune response, hereby we hope to introduce the possibility of a new treatment to improve patient outcome and survival.
The objective of this study is to obtain preliminary data on variability in PSMA expression by comparing the tracer uptake on conventional clinical 68Ga-PSMA PET/CT with an additional 68Ga-PSMA PET/CT (4 weeks later) within primary prostate cancer…
To develop and evaluate an adaptive MRI-only workflow for the MR-linac treatment in breast cancer patients eligible for APBI, regional lymph node irradiation or a radiotherapy boost on tumor positive lymph nodes. Furthermore, to investigate whether…
First, the threshold for the biomarkers of 31P-MRS will be determined. These biomarkers can indicate whether a patient with breast cancer benefit from the neoadjuvant chemotherapy (NAC). Then it is determined whether a (combination of) biomarker(s)…
Primary objective: to study the (cost) effectiveness of double layer closure of the uterine scar after a caesarean delivery, in comparison to single layer closure, in the prevention of niche development and related menstrual spotting.Secondary…
To assess the safety and tolerability of adjuvant treatment with olaparib
This DCOG-LATER project proposal aims to characterize the overall, disease and treatment-related risks of sexual dysfunction and delays in psychosexual development in a Dutch cohort of 5-year CCS treated in the period 1960-2001 and to evaluate the…
The objective of this study is to assess the costs and effects of two strategiesof tubaI testing during the fertility work-up, one based on the new technique hysterosalpingo-foam sonography (HyFoSy) (innovative strategy) and the other on…
Primary Objective* To demonstrate that avelumab given alone or in combination with Pegylatedliposomal doxorubicin (PLD) is superior to PLD alone in prolonging Overall Survival(OS) in patients with platinum -resistant/platinum-refractory ovarian…
The primary objective of this research is to compare the efficacy of continuing treatment with enzalutamide after adding docetaxel and prednisolone versus placebo plus docetaxel and prednisolone, as measured by progression-free survival (PFS) in…
1. To asses non-inferiority of BSC mesh in surgical success (= anatomic cure, subjective improvement and no re-treatment necessary) in the treatment of apical prolapse compared to unilateral SSLF at 12 months;2. Improvement of quality of life…