1301 results
Primary Objective: To compare the composition and functionality of neonatal microbiome arising from mothers receiving antibiotic prophylaxis before skin incision with the microbiome of neonates born when antibiotics are given after umbilical cord…
This study investigates the preventive action of formula with partially hydrolysed cow milk protein supplemented with pre- and probiotics in the development of allergy. The goal of the study is to investigate the efficacy, the growth and the safety…
1. To investigate the feasibility of web-based cognitive CBT among severely fatigued adolescent patients with an immune dysregulation disorder, and 2. To estimate intervention effects on reducing fatigue, associated chronic pain and fatigue related…
The purpose of the study is to investigate to what extent RO7049665 is tolerated. It will also be investigated how quickly and to what extent RO7049665 is absorbed and eliminated from the body (this is called pharmacokinetics). In addition, the…
The objective of the study is to determine the effect of BCG revaccination and high dose BCG vaccination on the induction and course of innate immune memory.
The primary objective of this study is to assess the prevalence of Temporomandibular Joint Disorders in (1) rheumatoid arthritis (RA) patients, (2) individuals at increased risk of RA, and (3) a control group without autoimmune diseases and to…
The goals of this study is to identify and validate recently discovered and novel biomarkers of pathophysiology, diagnosis, classification, disease activity, prognosis, treatment susceptibility, and treatment efficacy in IMIDs.
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
Primary Objective: Test the capacity of drug candidates to specifically inhibit the signalling pathways they target in human blood cells in vitro in the setting of human whole blood.Secondary Objective(s): Test whether drug candidates exert…
In this prospective observational cohort study we aim to study the potential clinical consequences of antibiotic use in early life, by focussing on the incidence of eczema, as well as food allergy, upper respiratory tract infections (URTI), lower…
To describe the pharmacokinetic (PK) profile and effectiveness of sarilumab in patients with sJIA in order to identifythe dose and regimen for continued development in this population.
To find molecular pathways active in ST of RA patients who did not respond to TNFi after 3 months of treatment with their first TNFi. This may aid in clinical decision making (on the group level) and may lead to discovering new drug targets.
Explore efficacy, safety, and feasibility (of an eventual future phase 3 trial) of intravenous immunoglobulins as treatment for patients with idiopathic inflammatory myopathies.
The primary objective of this study is to describe the effect of HSCT on the microangiopathy of SSc patients by using nailfold capillary microscopy (NCM). The secondary objective is to investigate the correlation between NCM findings and clinical…
To compare the effect of eltrombopag and IVIG on the achievement of the platelet count threshold before and after surgery.
Primary objective:The primary objective of the study is to determine the clinical performance of RABIOPRED test that would enable identification of patients with RA who are non-responders to anti-TNF*. Secondary objective:To explore, develop and…
The Primary objective is to determine whether the administration of ACH 0144471 can increase C3 levels in patients with low C3 levels due to either C3G or IC-MPGN.The secondary objectives are:* To evaluate the safety and tolerability of ACH 0144471…
The aim is to investigate the differences in pathogenesis of nonbullous and bullous pemphigoid by comparing gene expression, and the presence of activated and apoptotic eosinophils and IL-31 expression in skin, blood and blister fluid of both…
To describe the pharmacokinetic (PK) profile and effectiveness of sarilumab in patients with pcJIA in order to identifythe dose and regimen for continued development in this population.
Primary objectives and hypotises: In adults with active nr-axSpA who attain inactive disease after receiving open-label golimumab during a 10-month run-in (Period 1):Primary Objective: To evaluate the effect of treatment withdrawal vs continued…