2770 results
The primary objective of this study is to evaluate the safety of open-label galcanezumab within the context of expected medical practice in eligible patients with episodic or chronic cluster headache. The secondary endpoints are to characterize the…
The primary objective of the current study is to compare the presence or absence of arterial vessel wall abnormalities in the intracranial posterior circulation in patients with TIA or ischemic stroke with those of healthy controls using 7.0 tesla…
To investigate the effects of the cognitive behavioural intervention GEXP on physical activity and quality of life, hereby targeting specific fears in patients with PDN.Hypothesis: GEXP, as addition to usual care, increases the levels of physical…
Primary Objective Blinded Phase:• To evaluate the efficacy of GWP42003-P as add-on therapy in reducing the frequency of seizures when compared with placebo in patients with TSC.Open-label Extension:• To evaluate via the adverse events (AE) profile…
In this pilot study we want to investigate if 3D ultrasound can adequately visualize long nerve tracts and if 3D reconstructions of nerves and volumetric measurements can be made with this technique. If this is the case, this could not only decrease…
To demonstrate that SCS is capable of treating otherwise refractory neuropathic pain after chemotherapy / radiotherapy.
Primary Objective: To optimize the current DBS-treatment of advanced PD. For the primary objective the following research questions will be answered: By performing STN DBS under general anesthesia, will there be a significant reduction in cognitive…
The goal of this research project is to evaluate effectiveness of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a co-morbid depressive symptoms. With the online guided…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with symptomatic SVDs, relative to controlsSecondary Objective(s): To establish how microvascular function relates to:• parenchymal lesion…
Primary objective: To evaluate the efficacy of IVIg treatment (4 courses of treatment, 3 weeks apart) compared to placebo on pain alleviation. Secondary objectives: 1. Pain intensity, pain qualities, and other SFN related complaints, daily and…
Our main objective is to assess the difference in PIPR after a blue-light stimulus between hypopituitarism patients with and without a history of CC. Secondary objectives include differences in subjective and objective sleep quality, sleep-wake…
To study cognitive and behavioral outcome and resting-state dynamics in children with a history of perinatal asphyxia before and after the introduction of hyothermia and to compare these data with a group of controls.
To explore the neurophysiological and functional neuroimaging effects of Zolpidem on brain function in AM patients.
To elucidate the role of cortical inhibition in PGES (pilot).
1.The first objective is to determine the nature and spatial distribution of sonographic abnormalities in demyelinating and axonal polyneuropathies of different etiologies. 2.On the basis of the findings in objective 1, we define a standardized HRUS…
Our objective is to get insight into whether and how the visual system reorganises after acquiring HH. Visual processing will be investigated and cortical reorganisation at a structural level will be examined. For this purpose, we will assess…
The primary objective of this study is to evaluate the short term safety and tolerability, and pharmacokinetic properties of 2-IB when administered to adult patients after OHCA. Secondary objectives include safety and efficacy parameters at 30 days…
The objective of this study is to investigate the effect of virtual reality training, given between 2 weeks and 6 months after stroke, on participation and subjective physical functioning in independently living patients .Primary research question:…
The objectives are to evaluate the long-term safety and tolerability profile of aducanumab in subjects with early AD, and to evaluate the long-term efficacy of aducanumab treatment as measured by clinical, radiological and additional assessments…
The main goal of this project is to develop and validate a practical method to quantify slow vision. We will develop new tools to measure *perception time* during the assessment of visual acuity.