850 results
Investigation of pelvic blood circulation by MRI in women with a gynaecological cancer who will have curative radiotherapy with or without weekly HT for inoperable pelvic tumours.
In this prospective observational study, the effects of our anticoagulation strategy during flow reduction trials will be studied. The results may help in performing safe flow reduction trials of adequate length, to be able to better decide whether…
The aim of this study is to improve the conservative management of OCLs of the talus in the skeletally immature due to the comparison of two different conservative strategies. An optimal conservative treatment can result in a better quality of life…
To explore cardiovascular remodelling with subsequent altered cardiac function (assessed as strain rate) in extremely premature neonates (born <30 weeks and/or birth weight < 1000 gram) with FGR.
• The primary objective is to demonstrate non-inferiority of the detection rate of clinically significant prostate cancer (defined as GG >= 2) in targeted biopsies based on PCaVision imaging (PCaVision pathway) in comparison with the…
The primary objective of this study is to show immunological efficacy of autologous tumor-lysate loaded XP-DC in epithelial ovarian cancerpatients undergoing (neo-)adjuvant chemotherapy. The secondary objectives are the safety and feasibility of…
Primary objective:To assess, in an international pediatric study, the efficacy, in terms of event-free survival, of a combination of ATO and ATRA in newly diagnosed SR APL children and adolescents and to explore the safety and efficacy of a…
Primary objective:-To confirm that the Event-Free Survival (EFS) in patients >= 3 years of age with WHO grade IV/CNS WHO grade 4 and WHO grade III/CNS WHOgrade 3 diffuse high grade gliomas as well as diffuse high grade gliomas without a…
In the ASAP study, we aim to investigate pain associated with capillary sampling in a population of patients with serious psychiatric problems, compared to pain associated with standard venous access. This study is a pilot for a planned larger study…
Primary objective (after 1 year)- To evaluate the effectiveness of the nurse-led GILL eHealth intervention in patients with serious mental illnessSecundary objectives (after 1 year)- Improve metabolic syndrome severity- Improve fitness, physical…
To determine outcomes in long-term surviving brain metastases patients (>=2 years after diagnosis of brain metastases) treated with immunotherapy or targeted therapy.
The hypothesis is that personalised and risk-adapted treatment will improve outcome and reduce toxicity in post-pubertal patients with medulloblastoma.A further hypothesis is that clinical, magnetic resonance imaging (MRI) and voxel-based…
Primary Objective:1)To examine whether exposure to bullying victimization in adolescence is associated with the CTRA transcriptome profile(increased pro-inflammatory gene expression and decreased antiviral and antibody-related gene expression) in…
The goal of the study is to explore the effects on quality of life of an experimental treatment module that attempts to change trauma related attributions and cognitions in patients with remaining PTSD symptoms.
The specific aim of the current study is to investigate the impact of oncological treatment and multiple GA in Rb survivors and Rb risk carriers (8-35 years) on cognitive functioning, psychosocial functioning and HRQoL. Furthermore, psychological…
To investigate and define the most optimal technical acquisition parameters for V/Q PET/CT
The current study investigates the effectiveness of an intervention that focusses on the adaptive emotion regulation strategy cognitive reappraisal for people with EDs in the reduction of anxiety. This intervention will be compared to a control task…
The overarching aim of the Axial Involvement in Psoriatic Arthritis (AXIS) study is to systematically evaluate clinical and imaging manifestations indicative of axial involvement in patients with PsA to develop classification criteria and a unified…
To validate the method of measuring torsional eye movementsTo measure 3D eye movementsTo assess the age dependency of the responsesTo measure the gain of eye- versus headmovement and retinal slip velocity in clinical diagnosis by comparing patients…
The research objective is to obtain a more targeted RFTC treatment strategy by gaining more insight into the organization of epilepsy networks. We will study how RFTC affects large-scale brain networks in focal epilepsy and whether these network…