16549 results
The primary objective is to determine the impact of HER2 expression in CTCs taken at baseline on outcome to AIs in metastatic breast cancer patients with an ER-positive primary tumor. Secondary objectives are to determine impact of HER2 expression…
Primary Objective:- To provide continued access to atezolizumab based therapy and/or comparator agent(s) for eligible patients still on study treatment at the time of the parent study closure.Secondary Objectives:- Safety Objective: To evaluate the…
The main objective of the present study is to determine the role of dopamine and stress in functional connectivity in neural substrates for habitual- and goal-directed behaviour and their effects in subsequent behaviour.
The objective of the study is to evaluate the efficacy and safety of a single sub-retinal injection of AAV2-REP1 in subjects with choroideremia (CHM).
The purpose of the Endurant Evo International Clinical Trial is to evaluate the safety and effectiveness of the Endurant Evo AAA Stent graft system for endovascular treatment of subjects with infrarenal abdominal aortic or aortoiliac aneurysms.
Primary objective: To investigate the feasibility of the adaptive radiotherapy scheme.Secundary objectives:To examine the toxicity of the adaptive RT schemeTo investigate the locoregional tumor controlTo examine the prognostic value of the different…
Primary objectives are:1.1) to study the effect of oral administration of morphine SR on health-related quality of life; 1.2) to explore whether morphine SR leads to respiratory adverse effects in patients with advanced COPD. Secondary objectives…
The primary objective of this study is:-To evaluate whether selonsertib (SEL, previously known as GS- 4997) can cause fibrosis regression and reduce progression tocirrhosis and associated complications in subjects with NASH and bridging (F3)…
The objective of this project is to evaluate the effect of SuperFIT on BMI and several related healthy behaviours. Further, a process evaluation of the development and implementation of SuperFIT will be performed.
Study the changing immunophenotype and cell numbers after extensive surgical intervention (total hip arthroplasty) and limited tissue damage (knee arthroscopy), to identify the role of monocyte subpopulations in response to tissue damage. This could…
The primary objective of this study is to evaluate the safety of open-label galcanezumab within the context of expected medical practice in eligible patients with episodic or chronic cluster headache. The secondary endpoints are to characterize the…
To evaluate the efficacy ofa. early intensification of rituximab combined with 2-weekly CHOP+G-CSF (R-CHOP14) in remission induction treatment in comparison to standard R-CHOP14b. maintenance treatment with rituximab in patients in remission after R…
Primary:- To evaluate the efficacy of Oxabact® following 52 weeks treatment in patients with maintained kidney function but below the lower limit of the normal range (eGFR < 90 ml/min/1.73 m2) and a total plasma oxalate concentration >…
n.v.t.
Primary Objectives: 1) to investigate whether the neural responses during acquisition and extinction of cue-reward associations differ between obese and normal weight individuals; 2) to investigate whether the neural correlates of self-control in…
-To demonstrate the value of MRI in the initial staging of bladder tumours-To evaluate the feasibility of the use of MRI to delineate bladder tumours for planning GTV for external beam radiotherapy
- To assess the safety and tolerability of live-attenuated RSV vaccine in healthy adults.- To assess the immunogenicity of the live-attenuated RSV vaccine (systemic and mucosal immunity) - To assess the viral load/shedding of the live-attenuated RSV…
Primary objective is to gain insight into risk acceptation of serious adverse events (<30 days) in bariatric surgery. Secondary objectives are the expected weight loss, risk acceptation of mortality, risk acceptation of serious adverse events…
To assess the effectiveness of perforation and different injection therapies (autologous blood and dextrose) in the treatment of Lateral Epicondylitis of the elbow. The primary objective of our study is examining the change in pain score in the…
To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.