2107 results
To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.
This trial is intended to evaluate the safety and effectiveness of St. Jude Medical*s AMPLATZERTM AmuletTM device (Amulet) in patients with non-valvular atrial fibrillation who are at increased risk for stroke and systemic embolism. The trial will…
1. To assess whether nocturnal hemodialysis and renal transplantation give less progression of arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;2. To identify the risk factors for arterial calcification in…
The aim of this study is to examine the effectiveness of a nurse-coordinated Cardiac Care Bridge program consisting of care coordination, cardiovascular risk management and home-based rehabilitation for high-risk cardiac patients of 70 years and…
Safety and electrical performances evaluation of Navigo left ventricular leads with an IS4 connector, which are used at the implant of a cardiac resynchronisation system.
The aim of the present pilot study is to investigate whether nHFT of different settings (with different flow rates and additional amounts of oxygen) stabilizes respiration and thus improves AHI index and promotes compliance with the therapy in…
The primary objectives of this project are the identification of biomarkers in the blood and skeletal muscle that can improve the diagnosis of viral myocarditis and the expansion and improvement of the viral diagnostics in these patients. However,…
To validate the use of the Livv Mobiel ECG as a reliable office/bedside screening tool in primary care practice
The purpose of this clinical investigation is to assess the impact of the MultiPoint Pacing (MPP)feature at 12 months in the treatment of patients that are not responding to standard CardiacResynchronization Therapy (CRT)
- To document the average progression of AVS in a large population of patients with mild to moderate AVS.- To assess the prevalence of elevated Lp(a) among patients with mild to moderate AVS.- To identify lipid and genetic risk factors for AVS.
The primary objective of this study is to evaluate the short term safety and tolerability, and pharmacokinetic properties of 2-IB when administered to adult patients after OHCA. Secondary objectives include safety and efficacy parameters at 30 days…
Primary Objective: Identification of patient characteristics, echocardiographic measurements and biomarkers that can contribute to a better selection of patients that benefit from percutaneous ASD closure at adult age. Secondary Objectives:-…
Primary ObjectiveThe primary objective is to evaluate the effectiveness of adding Epanova to statin therapy (with or without ezetimibe) for lowering MACE (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, emergent/elective…
The primary objective is to establish the non-inferiority of the Synergy stent relative to the Xience stent for prevention of MACE. The effect measure is the difference in the rate of MACE in patients randomized to treatment with the Synergy ( index…
The aim of the study is to test the hypothesis that intermittent intravenous paracetamol administration in children after cardiac surgery will result in a reduction of at least 30% of the cumulative morphine requirement.
The FAST Therapy Trial is a prospective trial of patients with a new diagnosis of fetal SVA aimed to compare the impact of different perinatal treatment strategies from the time of SVA diagnosis to birth or death1) The primary outcome will be the…
The study will gain information on 3D movements / curvatures of the Reliance 4-Front and Reliance 4-Site ICD leads in vivo. We expect that the movements will be influenced by the type of lead (lead stiffness, which is different between the 2 lead…
This study aims to better diagnose cardiomyopathy in the increasing high-risk populations of chronic hypertension, type two diabetes mellitus, and obesity/overweight by providing gender specific cardiac MRI cut-off values for cardiac volumes,…
The primary objective of this trial is to test the safety and efficacy of Perceval valve versus standard sutured stented bioprosthetic aortic valves among the intended trial population. The secondary objective is to compare all relevant device and…
Primary Objective: Identification of genetic variants causative of CHD. Expression of candidate genes in a zebrafish model. Overall goal is to gain insight in cardiac development by expanding our knowledge of genetic components in de novo and…