8961 results
The primary objective of the study is to demonstrate clinically relevant statistical superiority in progression-free survival (PFS) with GClb compared to RClb and Clb alone and RClb compared to Clb [GClb vs Clb; GClb vs RClb; RClb vs Clb] in…
Primary Objective: What are the consequences of irradiation for the human jaw bone and oral mucosa on a macroscopic, microscopic and molecular level?Can possible prognostic factors be identified for the occurrence of peri-implantitis, dental implant…
To determine the maximum tolerated dose (MTD), dose limiting toxicities (DLT), and optimal dose of docetaxel that can safely be administered to patients with cancer in a weekly schedule. amendment 1The objective of the first amendment is to…
1. Evaluation of gene-expression profiles of endometria of PCOS women compared to normal ovulatory women2. Identify genes and pathways which contribute to a high rate of miscarriages of PCOS women3. Identify genes and pathways related to the high…
To assess the efficacy, measured as progression free survival, and safety of Selumetinib in combination with docetaxel, compared to docetaxel alone, in patients receiving second line treatment for KRAS mutation-positive, locally advanced or…
Produce a reproducible method for enumeration of CECs and CEPs in peripheral blood in order to further study the usefulness of CECs and CEPs as a biomarker in LDM therapy.
The purpose of the GLOBAL study is to perform whole-genome genotyping, next-generation deep resequencing, gene expression profiling, metabolomics, lipidomics and proteomics of atherosclerosis in patients phenotyped using advanced CT-based imaging…
The main objective is to evaluate the facial function in patients with UCM. In this study we set out to evaluate how the facial deformity influences the self-esteem and self-evaluation i.e. satisfaction of the patients and what the valence is of…
Primary Objective: - to study the influence of administration aprepitant (Emend ®) on the clearance of fentanyl, in patients using a stable dose of the fentanyl patch (Durogesic ®).Stable dose is defined as using the same dose of fentanyl during at…
Primary: to evaluate and compare the efficacy of:1) PDL treatment followed by topical sirolimus application after Er:Yag laser ablation of the stratum corneum in PWS 2) PDL treatment followed by topical sirolimus application without Er:Yag laser…
Primary Objective: - Antibodies to the hepatitis B surface antigen (anti-HBs) levels 30 days after the last hepatitis B vaccine dose (11 months) in children from IBD mothers treated with anti-TNF compared to children from IBD mothers not treated…
This study addresses the following three questions:1. How do fear memories change over time?2. How is the context of fear coded in the brain?3. How can the process of excessive strengthening of fear memory be disrupted
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
Evaluation of a multidisciplinary ICT SMS for children with CD.
Primary objective: to define the maximal tolerated dose (MTD) of Olaparib in combination with high dose radiotherapy with and without daily dose cisplatin in locally advanced non-small cell lung carcinoma.
The main objective of this project is to evaluate the effectiveness and cost-effectiveness of minimal interventional procedures as an add-on to a multidisciplinary pain program for patients with chronic mechanical low back pain who are referred to a…
The main objective of this study is to compare the femur tunnel positioning after AMP, TLS and TT reconstruction techniques. We will also look at the relation between tunnel positioning and tunnel widening.
The aim of the study is to create and optimize a DWI MRI scan protocol to assess thymic masses.
Our primary objective is to compare pre-treatment with the standard low calorie diet with pre-treatment with supplemental omega-3 fatty acids on liver volume. Secondary objectives are patient satisfaction about different dietary pre-treatments, the…