1224 results
The main objective of this study is to determine how well the Multiple Screener© can differentiate between patients with no cognitive deficits, mild cognitive deficits and cognitive impairment. Additionally, we aim to confirm the observed accuracy…
Primary:• To compare the efficacy of magrolimab + venetoclax + azacitidine versus placebo + venetoclax + azacitidine in patients with previously untreated acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy as measured by…
Primary objective:• Evaluate the anti-tumor activity of GEN1046 as monotherapy and in combination with pembrolizumab in subjects with relapsed/refractory metastatic NSCLCSecondary objectives:• Evaluate time to onset and durability of the anti tumor…
The primary objective is to study the effect of naltrexone/bupropion in combination with the BOT module on successful weight loss(>5% weight loss) after 22 weeks in patients with weight regain after bariatric surgery, compared to the regular…
3.1 Primary Objective• Feasibility of Magtrace® as a tracer in SLN sampling in early stage EOC.3.2 Secondary Objectives• Comparison of detection rate between MagTrace® and 99mTco In the general cohorto In primary staging laparotomyo In secondary…
The objective of this study is to:1) explore the feasibility (recruitment, adherence, and absence of major technical problems) of using both medical-grade and consumer grade wearables for continuous measurement of physical activity, posture, balance…
This study evaluates the impact of the various outcomes of prenatal exome sequencing (definitive diagnosis, probable diagnosis and incidental findings) on clinical decision making and on parental psychological wellbeing, compared between different…
To evaluate the effects of a bariatric surgery strategy on clinical endpoints, cardiac parameters and functional status in patients with obesity (with BMI 32-40 kg/m2) and symptomatic HF with preserved or mildly reduced LVEF in combination with AF.
Our primary objective is to determine how often and to what extent potentially pre-malignant oral fields extend beyond their visible lesion. If those "underestimated" lesions have a greater chance to recur, narrow band imaging-guided…
The primary objective of this randomized controlled trial is to investigate the effect of the VR-TRAC on aggression in a prison-based population.
1. study the effects of an 8-week high-intensity interval training on motor and non-motor aspects (primary outcome: anxiety and depression) of Parkinson's disease and Multiple Sclerosis, compared to traditional continuous aerobic training and…
The Primary Objective of this Clinical Trial is to evaluate the long-term safety and tolerability of litifilimab in participants with active SLE.The Secondary Objectives of this Clinical Trial are:- to evaluate the long-term effect of litifilimab on…
To prospectively evaluate the (cost)-effectiveness of LITT plus chemoradiation therapy (CRT) vs. CRT alone in patients with primary irresectable glioblastoma (GBM).
The objective is to obtain insight into a dose-dependent effect of vitamin K2 on oxidative stress and specific markers of the immune system. The primary objective is to investigate the effect of vitamin K2 on oxidative damage to lipids by measuring…
To prospectively evaluate the diagnostic accuracy of dynamic cardiac CT in addition to and in comparison with TEE in unselected patients with a clinical suspicion of native valve endocarditis.
Part A (Single Ascending Dose):Primary: To assess the safety and tolerability of single oral doses of PRAX-628 Secondary: To evaluate the pharmacokinetics (PK) of single oral doses of PRAX-628 Part B (Multiple Ascending Dose):Primary: To assess the…
To assess the efficacy of treatment with Endocalyx for chronic heart failure.
The objectives of the study are to assess safety and tolerability, pharmacokinetics (PK), and biological activity (including efficacy and pharmacodynamics [PD]) of multiple subcutaneous doses of pegcetacoplan in pediatric patients with paroxysmal…
To evaluate the effect of digital self-monitoring-based management of relapsing and remitting multiple sclerosis on self-efficacy, clinical outcome measures and cost-effectiveness
This project aims to assess the effect of laser therapy on the blood vessels and (peripheral) innervation of psoriasis plaques. The primary objective is to quantify the regression and recovery of nerves compared to blood vessels. We hypothesize that…