65 results
The main objective is to study the effect of a nutritional intervention on white matter integrity at the corrected age of three months in infants born at a gestational age <30+0 weeks. Secondary objectives of the study are to determine the…
PrimaryTo characterise the single and multiple dose to steady state pharmacokinetics of IV zanamivirin hospitalised neonates and infants under 6 months of age with influenza infection.SecondaryTo evaluate the safety and tolerability of IV zanamivir…
To compare the effect of two target ranges (91%-95% and 92%-96%) while on automated oxygen control on the time spent under the target range in preterm infants.
The primary objective of this pilot trial is to evaluate if adding mitoPO2 monitoring to standard anaesthetic management enables tissue oxygenation optimisation.
Evaluate the safety and feasibility of providing automated tactile stimulation in response to apnea, bradycardia and/or desaturation using the BreatheBuddy.
The specific trial aim is to establish whether the use of a high, dynamic 8-12 cmH2O PEEP level strategy to support the lung during stabilisation at birth, compared with a static 5-6 cmH2O PEEP level strategy, increases the rate of survival without…
This study's first objective is to assess lung mechanics (measured with FOT) in mechanically ventilated infants, in the clinical practice of the NICU, with intermittent measurements during the entire period of mechanical ventilation. The FOT…
The aim of this study is to visualize the position and movement of the vocal cords duringnon-invasive respiratory support of preterm infants after birth.
Primary objective: To assess the efficacy of treatment with ELGN-2112 as compared to placebo on intestinal malabsorption in preterm infants as measured by the time to full enteral feeding. Defined as first day of reaching three consecutive days of…
The SILVER study aims to give insight into the half-life of maternally acquired antibodies in preterms and the foetus to mother transfer function. These findings have implications for understanding infectious disease susceptibility, vaccine…
Primary Objective: to develop and evaluate a machine learning (ML) prediction model of brain injury in neonates at high-risk for CP to predict motor, behavioral, and cognitive outcome more accurately.This aim will be achieved by: developing and…
The primary objective of this study is to evaluate the feasibility of antenatal paracetamol/placebo administration to pregnant women 0.5-2 hours prior to birth.The secondary objective of this study is to compare the effect of antenatal acetaminophen…
Comparison of prenatal and postnatal cardiac function assessed by echocardiography using 2-D, 3-D, pulsed wave Doppler, Tissue Doppler and speckle tracking (strain and strain rate) between fetuses/neonates with structural heart disease, fetuses/…
The aim of this study is to evaluate the feasibility of the E-TOP module for both VP infants as an addition to the TOP program as well as for MP infants in an adapted TOP program.
Primary objective: To obtain a detailed immunological profile of children presenting to Dutch hospitals with acute SARS-CoV-2 infection or with a SARS-CoV-2 related post-infectious inflammatory syndrome. Secondary objectives: (1) To correlate the…
We aim to study the patient specific threshold for arterial blood pressure to maintain adequate cerebral perfusion (CBFV) in the perioperative setting and the association between perioperative abnormalities with postoperative brain damage and…
Our main objective is to explore the relationship between nutritional intake, growth, body composition and brain development. Hereby we want to improve our knowledge about how to feed the preterm infant in a way that contributes to a better…
To investigate the relationship between body composition and parenteral nutrition in children with intestinal failure at 6 months corrected age. The ultimate goil of this study is to optimize the treatment of children with intestinal failure by…
To analyze the effect of early (12 weeks corrected age) versus late (17 weeks corrected age) introduction of complementary feeding on obesity at the age of 2 years in preterm infants. Furthermore, the effect of complementary feeding on body…
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…