140 results
There might be discrepancies in number and type of Cancer Predisposition Syndrome diagnoses between the genotype first and the phenotype first approach.
A decrease in the incidence of central line-associated bloodstream infections in the investigational study group, compared to the control group.
To assess the PK/PD relationship of prednisolone as either prophylaxis or therapy of GVHD in children after HCT.
At least 90% of the subjects, with 95% confidence, will tolerate the test formula.
The test product supports normal physical growth in healthy term infants
Critical illness, along with the lack of zeitgebers on the PICU environment, and iatrogenic influences like medication and procedures, results in disturbed circadian rhythms in critically ill children, which is important for their recovery.
We hypothesize that functional Near Infrared Spectroscopy (fNIRS), eye-tracking, Indirect Calorimetry (IC), the BOD POD, and Bio-Impedance Analysis (BIA) are feasible outcome measures for children with Angelman syndrome.
Primary Objectives: -To evaluate if the treatment of Low Risk HB can be reduced (Group B1) -To compare different induction treatment regimens for Intermediate risk HB (Group C) -To compare different post induction treatment regimens for…
The main objective of this study is to analyze the effect of early (12 weeks corrected age) versus late (17 weeks corrected age) introduction of complementary food (weaning) on the prevalence of obesity at the age of 2 years in preterm infants.…
IV sildenafil is superior to iNO for the treatment of pulmonary hypertension in CDH newborns and should be considered as the drug of first choice in the future
To analyze the number of patients with (germline/somatic) actionable molecular aberrations in patients with relapsed/refractory pediatric tumors for whom no standard treatment or study protocol is available.
The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…
In 2004, a multidisciplinary team of clinicians and researchers in the UZ Leuven hospital started to collaborate on the rare problem of cancer during pregnancy. The collaboration between gynaecologists, pediatricians, hematologists, farmacologists,…
PHASE 1 OBJECTIVES:Primary:To determine the safety of oral larotrectinib , including dose-limiting toxicity (DLT), in pediatric patients with advanced solid or primary central nervous system (CNS) tumors. PHASE 2 OBJECTIVES:Primary Objective:To…
The primary objective of the first randomized question (R1) open for allLBL patients (pts) of the core study cohort, is to evaluate whether thecumulative incidence of relapses in the central nervous system can bedecreased by substituting prednisone…
To assess the PK/PD relationship of prednisolone as either prophylaxis or therapy of GVHD in children after HCT.
The central aim of the POEM Study: to investigate whether the early start of metformin on top of standard care may improve the treatment of GDM for mother and child. Metformin is used as a tool to reduce insulin resistance, the underlying cause of…
Our main question is: How does GDM brain immaturity affect skills that are critical for later language development? To answer this question, we will assess two skills in GDM infants and compare them to term controls in two independent (separate)…
Primary objective:To assess, in an international pediatric study, the efficacy, in terms of event-free survival, of a combination of ATO and ATRA in newly diagnosed SR APL children and adolescents and to explore the safety and efficacy of a…
Primary Objective:To investigate change in fat mass index between 6 and 12 months of age in infants receiving Nuturis® formula feeding versus standard formula feeding during the first 6 months of life.Secondary Objectives:- To investigate change in…