2398 results
Primary Objective:- To provide continued access to atezolizumab based therapy and/or comparator agent(s) for eligible patients still on study treatment at the time of the parent study closure.Secondary Objectives:- Safety Objective: To evaluate the…
Primary objective: To investigate the feasibility of the adaptive radiotherapy scheme.Secundary objectives:To examine the toxicity of the adaptive RT schemeTo investigate the locoregional tumor controlTo examine the prognostic value of the different…
The primary objective of this study is:-To evaluate whether selonsertib (SEL, previously known as GS- 4997) can cause fibrosis regression and reduce progression tocirrhosis and associated complications in subjects with NASH and bridging (F3)…
The primary objective of this study is to evaluate the safety of open-label galcanezumab within the context of expected medical practice in eligible patients with episodic or chronic cluster headache. The secondary endpoints are to characterize the…
Primary:- To evaluate the efficacy of Oxabact® following 52 weeks treatment in patients with maintained kidney function but below the lower limit of the normal range (eGFR < 90 ml/min/1.73 m2) and a total plasma oxalate concentration >…
n.v.t.
Primary Objectives: 1) to investigate whether the neural responses during acquisition and extinction of cue-reward associations differ between obese and normal weight individuals; 2) to investigate whether the neural correlates of self-control in…
To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.
This trial is intended to evaluate the safety and effectiveness of St. Jude Medical*s AMPLATZERTM AmuletTM device (Amulet) in patients with non-valvular atrial fibrillation who are at increased risk for stroke and systemic embolism. The trial will…
The aim of the present study is to conduct a randomised controlled trial (RCT) to assess the effectiveness of a guided web-based transdiagnostic intervention in treating student depression and anxiety.
Primary Objective Blinded Phase:• To evaluate the efficacy of GWP42003-P as add-on therapy in reducing the frequency of seizures when compared with placebo in patients with TSC.Open-label Extension:• To evaluate via the adverse events (AE) profile…
This study investigates the preventive action of formula with partially hydrolysed cow milk protein supplemented with pre- and probiotics in the development of allergy. The goal of the study is to investigate the efficacy, the growth and the safety…
PRIMARY* To demonstrate the non-inferiority of intravenous-to-oral antibiotic switch therapy in clinically stable neonates with probable bacterial infection compared to a complete course of intravenous antibiotic therapySECONDARY* To describe the…
In this pilot study we want to investigate if 3D ultrasound can adequately visualize long nerve tracts and if 3D reconstructions of nerves and volumetric measurements can be made with this technique. If this is the case, this could not only decrease…
The primary objective is to determine the efficacy of MagnetOs BCP granules in inducing adequate bone quantity and quality to support endosseous dental implants in the two-staged maxillary sinus floor augmentation procedure. Herein the treatment…
Safety and electrical performances evaluation of Navigo left ventricular leads with an IS4 connector, which are used at the implant of a cardiac resynchronisation system.
Evaluation of the effect of nivolumab and daratumumab with or without low dose cyclophosphamide in patients with relapsed/refractory multiple myeloma
Objective procedure 1:To assess the technical feasibility and safety of in-vivo focal imaging with CLE and OCT.Objective procedure 2: Primary Objective: To identify and define characteristics of prostate cancer on CLE and OCT and compare this with…
(1) To examine whether the exposure to BWL yields clinically significant reductions in CRF compared to exposure to dim white light in (non-)Hodgkin survivors. (2) To examine the effect of exposure to BWL compared to DWL on sleep quality and…
The primary objective of the current study is to determine the relevance, feasibility and strain for patients of the INPACT protocol.