27597 results
The purpose of this study is to evaluate the efficacy of oral ibandronate (versus placebo) added to the standard radiotherapy regimen for painful bone metastases to reduce pain, to reduce the need of analgesics, and to reduce skeletal-related events…
A 7-day course of antibiotic treatment is non-inferior to a 14-day course in febrile urinary tract infection.
Blue light glasses can manipulate (i.e., inhibite) body melatonine production to re-adjust the circadian rhythm of shift workers, thereby having the potential to enhance viglance, cognitive function, and positive mood during night shift work.
The purpose of this study is to demonstrate the added value of using 'LMA-S in the ambulance with CPR in the Netherlands indigent patients. The hypothesis is that the value of using the LMA-S is located in the safety and speed of placing the…
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…
To determine the epidemiology, diagnosis and prognosis of enterovirus (EV) and parechovirus (HPeV) infection in Dutch children. Hypotheses: 1. EVs are one of the most important viral agents of infection in Dutch children; 2. EVs are the major cause…
Postoperative change in deltoid volume following reverse shoulder arthroplasty is related to functional outcome
A safe RP2D of Vyxeos®/CPX-351 in combination with clofarabine can be identified in this phase 1b study.
With implementation of the AWR we expect a reduction in the total amount of radiographs requested, without missing any clinical relevant fractures. We also expect a reduction in overall waiting times at the ED and a total amount of cost savings…
Fatigue affects central nervous system function and, in the setting of the medical profession, could influence specialist performance, patient care and safety. ln contrast to other industries, for example the aviation industry, there are no "…
Benign liver tumors and cysts carry a significant burden on the quality of life in some cases. Apart from impairing symptoms, psychological burden might provide sufficient ground for surgical intervention. There is a variable approach to them…
Een klinisch behandelprogramma met een opnameduur van acht weken gevolgd door een intensief vervolgprogramma voor kinderen (8-19 jr.) met ernstige obesitas is kosten effectiever dan een klinische interventie met een opnameduur van zes maanden en…
Conditioning with hydrocortisone will result in altered endogenous cortisol during rest in the evocation phase.
Low-load blood flow restriction therapy has beneficial effects on postoperative quadriceps and hamstrings atrophy/strength, at 8 and 14 weeks after bone-patellar tendon-bone anterior cruciate ligament reconstruction, compared to standard care…
About 10-15% of the population suffers from chronic insomnia. Structurally poor sleep can have unpleasant consequences for people's health and quality of life. Therefore, proper treatments are of great importance. Fortunately, Cognitive…
We hypothesize that aromatase-inhibitors will have lower efficacies in the presence of an abundant estrobolome and high ß-glucuronidase activity. It’s also unclear whether microbiota influences intestinal absorption of tamoxifen’s related metabolite…
Background: Injury rate and injury severity of elderly cyclists due to self-induced cycle accidents increase with age. Starting at the age of 55 years, injury risk increases with a factor 4 at the age of 75 years. Injury mechanisms such as slippery…
Fluorescent near-infrared imaging can be used to identify the ureters using a low dose methylene blue.
Determining maximal tolerated dose hydroxy-ureum in combination with dose intense temozolomide in patients with recurrent glioblastoma