36835 resultaten
Tacrolimus (FK506) is the main immunosuppressant that is prescribed after kidney transplantation. One of the disadvantages of Tacrolimus is the small therapeutic window. In transplantation patients therapeutic drug monitoring is routinely performed…
We hypothesize that ID is an important factor in the limitation of exercise capacity in HFpEF. Systemic low-grade inflammation does not only lead to microvascular dysfunction but also to iron deficiency. Iron deficiency has a direct effect on the…
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
The overall aim of this study is to generate a first impression about the usability of the therapy-supportive Luca app with youngsters in youth mental healthcare. For this purpose, we will ask the following research questions: 1. How do therapists…
Based on literature we assume a 20% day 30 mortality of patients admitted to the hospital ward with COVID-19. We aim to lower this day 30 mortality to 10%.
the present study investigates whether a small-scale stay in an enriched green environment in a care center is related to a slower progression of cognitive functions, better mood, less behavioral problems, and a higher quality than if standard care…
Is there a diiference in antidepressant efficacy between ECT and a combination of ECT and nortriptyline? Does combination therapy with ECT and nortriptyline result in a faster antidepressant response compared with ECT monotherapy? Does combination…
The procoagulant state seen in patients with hiv can be a result of the immune activation due to the hiv infection itself or combination antiretroviral therapy (cART). In case the acquired thrombophilia is a result of immune activation, the…
ICT guided disease management combined with telemonitoring leads to a reduction of death and readmission for heart failure, and improves the quality of life.
The goal of EEG4STROKE is to test a device that enables paramedics to accurately diagnose patients with suspected stroke on site (in the ambulance or living room of the patient). EEG4STROKE will integrate hardware and software to triage stroke…
Primary objective: To test whether mucosal oxygen saturation has added value to endoscopy and histological examination. Secondary objectives: 1. To test whether detection of hypoxia dependent molecular changes in the mucosa can be used to improve…
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
HIV-infection and antiretroviral therapy use may lead to a diminished neurological and neurocognitive performance in HIV-infected children.
We hypothesize that participants in both groups improve on cognitive functioning after the intervention period, and that participants who will receive CIRCuiTS in combination with active tDCS will improve more than the participants who receive…
The implementation of the delirium part of the Vulnerable elderly project will improve when nurses have completed an e-learning tool regarding delirium care for elderly patients.
Early provision of AFOs (± 2 wks after stroke) is expected to positively affect walking impairments, mobility and activities of daily living after acute stroke compared to providing AFOs later on in the rehabilitation process (± 10 wks after stroke…
1) In what proportion of severe hypoxic COVID-19 patients on HFNC is invasive mechanical ventilation necessary? 2) In what proportion of severe hypoxic COVID-19 patients with an DNI code on HFNC results in progressive respiratory failure or death?
Since several years, anti-VEGF agents have become available for the treatment of neovascular age-related macular degeneration (AMD) and have substantially improved visual prognosis in patients suffering from this condition. The anti-VEGF agent used…
COPCA (Coping and Caring) intervention in infants at high risk for cerebral palsy will result in better functioning than Tradional Paediatric Therapy.