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A study to evaluate the different levels of attention and valence direction for erotic stimuli, in relation to genital and subjective sexual arousal in healthy female subjects and healthy female subjects with Female Sexual Dysfunction.

In the present placebo controlled study we will investigate the influence of valence on attention when viewing visual erotic stimuli. Especially when under the treatment condition of testosterone with sildenafil. In addition, we will investigate the…

OPTIcal diagnosis of T1 Colorectal carcinoma And depth of invasion in Large (≥20 mm) non- pedunculated colorectal lesions

We aim to test the accuracy of Western gastroenterologists in differentiating T1 CRCs from its precursor lesions and subsequently in estimating invasion depth

The effectiveness of een internet course for pregnant women with depressive and anxiety symptoms

An online intervention will be an effective intervention for treating affective symptoms in pregnancy and their complications by reaching more women and making therapy easier accessible

Effects of crisis cards/plans for people with psychotic illnesses, facilitated through local patient organisation and through clinician, on the number of crisiscontacts with mental health services and the numer of (cumpulsory) admissions.

N/A

Using the best wearable sensor in facilitating hands-free, sterile control in the operating room

OR workflow for surgeons needing to interact with the laparoscopic equipment during surgery is optimized using TedCube© in combination with the Myo™ gesture control armband and/or a wireless headset.

CArdiometabolic Risk reDuctIOn by Rimonabant: the Effectiveness in
Daily practice and its USE.

In the RIO study programme, the efficacy of rimonabant was examined. The next step is to assess the use of rimonabant, its safety and effectiveness in daily practice. In daily practice people also have other diseases, may use other medication and…

Characterizing the bone marrow environment in advanced-stage myelofibrosis. A PET/MRI study.

We hypothesize that by using different imaging techniques, we can give a good characterization of the bone marrow microenvironment in advanced-stage myelofibrosis, before and during treatment with ruxolitinib.

FEmoral BOne fracture study

We expect the protein synthesis rate in (avascular) femoral bone proximal to the fracture to be lower when compared to healthy femoral bone.

Insulin-induced microvascular dilatation during a physiological stimulus - Studies in hypertension and obesity.

We hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular…

Does booster influenza vaccination improve vaccination efficacy in patients with quiescent systemic lupus erythematosus?

SLE patients show a decreased humoral immune response to influenza vaccination, as compared to healthy controls. Furthermore the use of immunosuppressives is of influence on vaccination immunogenicity, it has been demonstrated that the use of drugs…

Radiotherapy with or without ibandronate in the treatment of painful bone metastases of prostate cancer.

The purpose of this study is to evaluate the efficacy of oral ibandronate (versus placebo) added to the standard radiotherapy regimen for painful bone metastases to reduce pain, to reduce the need of analgesics, and to reduce skeletal-related events…

Febrile Urinary Tract Infection Randomized Short Treatment Trial.

A 7-day course of antibiotic treatment is non-inferior to a 14-day course in febrile urinary tract infection.

Oral PHA-022121 for the acute treatment and prophylaxis Of angioedema attacks in Patients with Acquired C1-Inhibitor Deficiency

We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.

A Phase I/II study of Azacitidine (Vidaza®) in pediatric patients with relapsed high-grade pediatric MDS or JMML.

There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…

Kracht en functie na een omgekeerde schouderprothese

Postoperative change in deltoid volume following reverse shoulder arthroplasty is related to functional outcome

Vyxeos® and Clofarabine in relapsed/refractory pediatric AML

A safe RP2D of Vyxeos®/CPX-351 in combination with clofarabine can be identified in this phase 1b study.

Amsterdam Wrist Rules

With implementation of the AWR we expect a reduction in the total amount of radiographs requested, without missing any clinical relevant fractures. We also expect a reduction in overall waiting times at the ED and a total amount of cost savings…

FTOP - nationwide observational study

Fatigue affects central nervous system function and, in the setting of the medical profession, could influence specialist performance, patient care and safety. ln contrast to other industries, for example the aviation industry, there are no "…

A nationwide cohort study on benign liver tumors and cysts in the Netherlands

Benign liver tumors and cysts carry a significant burden on the quality of life in some cases. Apart from impairing symptoms, psychological burden might provide sufficient ground for surgical intervention. There is a variable approach to them…

Het HELIOS onderzoek naar behandeling van kinderen en adolescenten met ernstige obesitas.

Een klinisch behandelprogramma met een opnameduur van acht weken gevolgd door een intensief vervolgprogramma voor kinderen (8-19 jr.) met ernstige obesitas is kosten effectiever dan een klinische interventie met een opnameduur van zes maanden en…