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In recent years several studies have been published about colorectal interval carcinomas, carcinomas that develop in patients who are under colonoscopic surveillance. One of the reported explanations for interval carcinomas is incomplete removal of…
Age associated molecullar processess are involved in rotator cuff degeneration and the presence of rotator cuff tears
Treatment with Ivacaftor can lead to a therapeutic level of restoration of the CFTR protein channel activity in patients with a class III, S1251N gating mutation. This level of restoration is comparable to a combination of the natural food…
By using a surgical safety checklist, the incidence of postoperative complications will decrease.
1. Regular physical follow-up can partly be replaced by nurse-led telephone follow-up, with at least similar quality of life (QoL), in breast cancer patients treated with curative intent. ( change in QoL < 5 points) 2. An informative/…
(Short) stay and, if possible, treatment at the PMU, will give an improvement in regular psychometrics or at least in some of them.
Early diagnosis of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) combined with swift identification and treatment of pulmonary infections is important for the preservation of pulmonary function, quality of life and life expectancy. A…
Medication overuse headache (MOH) is a disorder that results from the overuse of analgesics, triptans or other acute headache medication. Patients overusing triptans are almost always patients with migraine as their primary headache. There is…
1. All obese patients have low-grade systemic inflammation characterized by IL-6, TNF-alfa, leptin and adiponectin. Patients with obesity and asthma have higher expression of these mediators and neutrophils in bronchial mucosa than obese patients…
Evaluation of efficacy and safety of two different formulas of alfa-Galactosidase A, agalsidase beta (FabrazymeTM) and agalsidase alpha (ReplagalTM) in an equal dose of 0,2 mg/kg in order to detect any differences between these two drugs.
Whole Body Vibration (WBV) applied via a chair has positive chronic effects on cognitive function of older people.
To determine the epidemiology, diagnosis and prognosis of enterovirus (EV) and parechovirus (HPeV) infection in Dutch children. Hypotheses: 1. EVs are one of the most important viral agents of infection in Dutch children; 2. EVs are the major cause…
Sunitinib, when given in a high-dose, intermittent schedule, may exhibit improved efficacy with an acceptable toxicity profile.
It is hypothesized that both positive verbal suggestions regarding an inert substance and a positive imagery exercise result in a lower sensitivity to physical sensations (pain, itch, and fatigue) than neutral verbal suggestions and/or neutral…
Eating rate may be related to overweight. Due to a high eating rate, there may not be sufficient time to develop appropriate feelings of satiety, leading to overconsumption. We hypothesise that when eating rate is high, the ad libitum food intake is…
Using Irreversible Electroporation on locally advanced pancreatic adenocarcinoma deemed unresectable during explorative laparotomy, will increase progression free survival and median overall survival.
We hypothesize that a conversation aid and information brochure for patients, and a communication training for physicians improves satisfaction and quality of the discussion about potential treatment restrictions at the internal medicine outpatient…
We believe that a routine graft biopsy at 6 and 12 months together with graft function represents the best surrogate marker for late graft loss.