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We hypothesize that subjects (Asian or Caucasian) with the COMTH allele (Val/Val polymorphism) respond stronger to the GT treatment than subjects with the COMTL allele (Met/Met polymorphism), consequently have an increased EE and that the genetic…
We hypothesize that systemic aPC will benefit patients with ALI/ARDS, as caused by inflammatory as well as infectious disorders, in terms of gas exchange, edema and capillary leak in these lungs, as well as in ventilator-days (duration of mechanical…
The past years, the use of smartwatches in medical science has increased. Recent systematic reviews have reported studies that used a smartwatch to measure activity level, eating behavior and seizures, among other things. However, these studies are…
We hypothesise that one year compression therapy after DVT is equally effective as two years in the prevention of the post-thrombotic syndrome - in selected patients.
We hypothesize that breast cancer organoids will result in a prospective clinical model that is predictive of treatment response.
The hypothesis is that drug-resistant epilepsy patients will report a significant increase in quality of life 1 and 2 years after resective epilepsy surgery. The study is a prospective cohort study. The study population consists of adult drug-…
T-cell inhibition with Mycophenolate Mofetil (MMF) attenuates T-cell number, T-cell activation and T-cell – monocyte interaction, thereby minimizing the T-cell-driven inflammatory amplification loop. The latter will contribute to improvement of anti…
The electrohysterogram is better predictor of preterm delivery than current diagnostics.
Which design of cognitive aid (emergency manual) is easier to use and results in less missed critical actions during anesthetic emergencies
Non-inferiority of anti-Pertussis Toxin (PT) IgG in term infants at 2m of age born of mothers having received a pertussis vaccine between 20-24w Gestational Age (GA) compared to a reference anti-PT IgG at 2m of age in a historical control group of…
The VAS score is lower in subjects with Sever’s disease after treatment with heel raise than in subjects treated with supervised strengthening exercises. The VAS score is lower in subjects with Sever’s disease after treatment with supervised…
It is not unusual for children to have an intermittent tiptoe gait when they start to walk. Older children with persistent tiptoe gait in absence of developmental, neurological or neuromuscular conditions, are diagnosed idiopathic toe walkers (ITW…
We hypothesize that exercise training positively affects cognitive functioning measured by standard neuropsychological tests, especially learning and memory. Furthermore, we hypothesize that exercise training will result in the following changes on…
In recent years several studies have been published about colorectal interval carcinomas, carcinomas that develop in patients who are under colonoscopic surveillance. One of the reported explanations for interval carcinomas is incomplete removal of…
Overfeeding disrupts the hypothalamic response to glucose ingestion in healthy men.
We hypothesize that it is safe to stop first-line nivolumab or pembrolizumab at confirmed response, while improving quality of life (QoL) and reducing the use of healthcare resources, and costs.
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the online self-management program for patients with Cardiovascular Risk 2. to identify outcome measures most likely to capture potential patient benefit…
10 Gy additional boost to the tumor bed will yield an increase in local control at 10 years from 88% to 93%, with still acceptable cosmesis.
1) It is expected that the percentage of days abstinent will be higher in both training interventions compared to the sham ApBM with religion-adapted ApBM having the biggest effect-size in this comparison. Also, it is expected that participants with…