299 resultaten
The overall 1- and 5-year survival rates after liver transplantation are nowadays well established at approximately 90% and 70%, respectively. Unfortunately, long-term patient survival rates after OLT lag behind, with an overall 20-year survival…
To determine the level of nilotinib detectable in seminal fluid of men treated with this tyrosine kinase inhibitor And to form an advise if condoms are necessary to protect their sexual partners from exposure to nilotinib.
High-dose single-fraction radiotherapy (SBRT) to the primary lung tumor combined with dual immune checkpoint inhibition is safe and feasible and will increase both the systemic response rate to these agents and induce more durable tumor responses…
We investigate the effectiveness of a multidisciplinary treatment Resolutions Approach (RA) in families with alleged child abuse supplemented with the assessment form of Turnell (Turnell et al., 2009). We investigate the effects of RA on the primary…
A limited endoscopoic assisted laparoscopic wedge resection of colon polyps is safe and effective.
Breast-conserving surgery followed by radiotherapy is a safe and effective procedure to treat early stage breast cancer. In many women, this type of treatment gives beside a good survival a good cosmetic result. However, some women will be troubled…
Patients's satisfaction will be good independable of the time interval between follow-up and meniscal allograft transplantation (MAT). Patient Reported Outcome Measures (PROMs) will be significantly higher postoperative compared to preoperative…
Cabazitaxel is a tubulin-binding taxane drug that improves survival of patients with docetaxel-metastatic-castration-resistant prostate cancer (mCRPC). Unfortunately, cabazitaxel is not effective in all patients and can have serious side effects.…
The Untire app will create awareness by proving psycho-education and will give insight in ones’ energy levels, ones’ thoughts and behaviors in relation to energy levels and provides exercises that help users to challenge ineffective thoughts and…
We hypothesize that aromatase-inhibitors will have lower efficacies in the presence of an abundant estrobolome and high ß-glucuronidase activity. It’s also unclear whether microbiota influences intestinal absorption of tamoxifen’s related metabolite…
the correspondence between orosensation of sweetness and post-oral sensation of calories influences resting energy expenditure, cerebral blood flow and gastric emptying, and more specifically that the “not sweet enough” beverage, that contains more…
We hypothesize that a certain shear load threshold exists, where an increase in the cytokine IL-1a is observed.
The aim is to examine the natural course of Acute Stress Disorder (ASD) symptoms (aim 1) and the effects of these symptoms on the development of Port-Traumatic Stress Disorder (PTSD) and patients¡¯ psychological distress (i.e., anxiety and…
To investigate the possibility to predict chemotherapy response using proliferation assays.
With help of the TOF watch, a reduction in muscle relaxation can be observed earlier. In this way, peroperative events (pain or contractions by the patient) can be prevented. Less peroperative events lead to less postoperative pain.
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
Trends in and variability of vital signs reveal hidden information about the state and deterioration of the patient compared to absolute values of vital signs.
Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
The association between BPP and NSSI is mediated by alexithymia