We hypothesize that a certain shear load threshold exists, where an increase in the cytokine IL-1a is observed.
Bron
Aandoening
Pressure ulcers
Decubitus
Doorligwonden
Ondersteuning
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
Primary outcome is the IL-1a concentration in the sebum layer. This concentration is used as biomarker for early detection of pressure ulcers.
Achtergrond van het onderzoek
10 healthy subjects are included for this research which focusses on reducing pressure ulcer prevalence.
Three different levels of shear load are applied to the volar aspect of the skin after which the concentration of IL-1a is measured using sebutape. It is expected that an increase in IL-1a is observed at a certain shear load threshold, which can be used to tailor surface such that they prevent or reduce pressure ulcers.
Doel van het onderzoek
We hypothesize that a certain shear load threshold exists, where an increase in the cytokine IL-1a is observed.
Onderzoeksopzet
Recruitement starts after acquiring METC approval.
10 Healthy subjects are to be included.
The measurements are plannned to start in June, and are planned to be finished by the end of July.
Onderzoeksproduct en/of interventie
A varying shear load is applied for 1 hour, which is repeated for three sessions. Before and after application of the shear load, a sebutape is applied to absorb the sebum which is present on top of the skin.
Publiek
M. Klaassen
Drienerlolaan 5
[default] 7522 NB
The Netherlands
0534896883
m.klaassen@utwente.nl
Wetenschappelijk
M. Klaassen
Drienerlolaan 5
[default] 7522 NB
The Netherlands
0534896883
m.klaassen@utwente.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age between 18 and 35
Healthy
Braden score > 20
BMI between 20 and 30 kg/m2
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Any history of skin diseases
Trauma at the volar aspect of the forearms
Known diseases such as: heart diseases, respiratory diseases, diabetes, other diseases to microcirculation, skin diseases, sensory diseases, muscle diseases
Pregnancy
Unable to sit still for 1 hour
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL6245 |
NTR-old | NTR6401 |
Ander register | : |