The overall 1- and 5-year survival rates after liver transplantation are nowadays well established at approximately 90% and 70%, respectively. Unfortunately, long-term patient survival rates after OLT lag behind, with an overall 20-year survival…
ID
Bron
Verkorte titel
Aandoening
Liver transplantation,
Ondersteuning
P.O. Box 30001<br>
9700 RB<br>
The Netherlands<br>
+31 (0)50 3616161
P.O. Box 30001<br>
9700 RB<br>
The Netherlands<br>
+31 (0)50 3616161
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
all-cause mortality
Achtergrond van het onderzoek
The last decades short-term survival in liver transplant recipients has been markedly improved, however long-term survival is still being restricted. Where most research has focused on immunosuppression, comorbidities and infections, we hypothesize that other, yet unknown, patient-related factors may influence long-term survival. One of these factors, among others, could be urinary creatinine excretion rate as an established marker of total body muscle mass. This study is a biobank and single-center observational cohort study to investigate this hypothesis.
Doel van het onderzoek
The overall 1- and 5-year survival rates after liver transplantation are nowadays well established at approximately 90% and 70%, respectively. Unfortunately, long-term patient survival rates after OLT lag behind, with an overall 20-year survival rate of approximately 50%. Where most research has focused on immunosuppression, comorbidities and infections, we hypothesize that other, yet unknown, patient-related factors may influence long-term survival. One of these factors, among others, could be urinary creatinine excretion rate as an established marker of total body muscle mass. This study is a biobank and observational cohort study to investigate this hypothesis.
Onderzoeksopzet
Baseline measurements, routine outpatient clinical visits
Onderzoeksproduct en/of interventie
No interventions, the cohort is observational
Publiek
V.E. de Meijer
Groningen 9713 GZ
The Netherlands
+31-50-3616161
Wetenschappelijk
V.E. de Meijer
Groningen 9713 GZ
The Netherlands
+31-50-3616161
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age >18years, prognosis > 1 year, stable outpatients situation
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Survival less than one year after liver transplantation, patients lost to follow-up
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6334 |
| NTR-old | NTR6650 |
| Ander register | : UMCG METc 2014/77 |