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We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…
Patients with a BMI > 30 kg/m2 in the ICU have a higher incidence of pressure ulcers and wound infections in the ICU compared with patients with a BMI 18-25kg/m2. They develop them sooner during admittance and the severity and time to…
A two-week daily treatment with NAC (2400 mg/d) will change glutamate concentrations in the dACC and striatum in nicotine dependent subjects, while no effect of placebo on glutamate concentrations is expected. Treatment with NAC will show positive…
Simplified FLT PET parameter.
It is hypothesized that a flexible stepped care program for depression reduces the incidence of depression, severity of depression and anxiety symptoms and healthcare costs among primary care patients with diabetes type 2 and/or CHD and sub…
To determine whether a second dose of IVIg in GBS patients with a poor prognosis improves functional outcome after 4 weeks. Secondary outcomes include functional outcome after 8, 12 and 26 weeks, duration of mechanical ventilation, length of…
Both intervention groups, ‘the stories we live by + counselor’ and ‘the stories we live by + peer contact’, are superior to the control group in terms of clinical outcomes (reduction of depressive symptoms and improvement of positive mental health).
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The hyperfiltration hypothesis implies that children with a solitary functioning kidney are at risk to develop hypertension, (micro)albuminuria and chronic kidney disease. We aim to develop an individualized risk profile for children with a solitary…
Currently the 3-year disease free survival of patients with locally advanced rectal cancer is about 50%. Current standard treatment for patients at high risk of failing locally and/or systemically includes pre-operative long course radiotherapy (5…
The aim of the study is to examine how different working memory interventions address to the neurocognitive functioning and academic performance of children with AD(H)D.
The main objective is to examine the efficacy of a combined errorless learning and Goal Management Training (GMT) intervention for treatment of executive problems of patients with acquired brain injury (ABI) in the chronic phase (>6 months…
We postulate that exhaled molecular profiling obtained from ‘breathprints’ by electronic nose: 1. Is associated with the level of asthma control and; 2. Is associated with an inflammatory profile in induced sputum and blood in steroiddependent…
1. The intervention 'Happiness Route' is effective in promoting positive mental health in comparison to a control condition that consists of optimized care-as-usual; 2. In comparison to the control condition, the intervention '…
The bioavailability and effectiveness of vitamin K tablets and solution are comparable.
Part A: In clinical practice the use of simplified quantitative methods and procedures can be fully validated against complex quantitative kinetic measures. Part B: Test-retest repetability of different SUV measures, metabolic and anatomic volume…
Hypersalivation or sialorrhea is one of the most frequently occuring side effects of clozapine use with an incidence ranging from 30 to 90%. In most cases it occurs at the start of clozapine treatment, mostly at night and persists during further…
Our first hypothesis is that in the two exisiting case management models, the persons with dementia will have less behaviour and mood problems than persons receiving usual care and informal caregivers experience better mental health compared to…
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