464 resultaten
We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…
Patients who will train with the SCRIPT-system will have similar or improved arm and hand function in comparison with the patients who receive conventional arm and hand exercises.
The aim is to investigate the effects, costs, and feasibility of an evidence-based professional-directed implementation strategy to implement the Dutch peri-operative guidelines, i.e. to achieve a higher adherence to these guidelines. It is…
Use of IBD-live for 1 year: 1. Reduces the relapse rate from 40% to 25%; 2. Increases quality of life (assessed with the IMPACT-III questionnaire).
1. Verbeteren van de overleving in vergelijking met de eerdere protocollen van de SKION, in het bijzonder ALL-9 and ALL-10. Doelstelling is om therapie te verminderen voor een deel van de patiënten (TEL/AML1, Down syndroom, geïsoleerd slechte…
Patients with a BMI > 30 kg/m2 in the ICU have a higher incidence of pressure ulcers and wound infections in the ICU compared with patients with a BMI 18-25kg/m2. They develop them sooner during admittance and the severity and time to…
The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using transpulmonary (advanced FloTrac software) and intermitted bolus thermodilution cardiac output in critical ill…
Relative to the control condition of 'recall only' the experimental condition of 'recall + eye movements' will produce a reduction in both the 1) subjective vividness/emotionality of the mental image and associated recall-induced…
We hypothesize that in rheumatoid arthritis (RA) patients responding to adalimumab, with high adalimumab serum concentrations at least 28 weeks after treatment initiation: 1. Lowering the serum concentrations through dose interval prolongation will…
We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.
For patients with severe symptomatic aortic valve disease, aortic valve replacement surgery is the treatment of choice. Two options exist: Mechanical and bioprosthetic aortic valve. The decision which valve type to choose is difficult, since in most…
The hypothesis is that an accurate history, conventional markers of sensitization, IgE antibodies in the serum and positive SPT, and more advanced techniques (MRAs and component resolved diagnosis (CRD)) might predict clinical allergy to cashew nuts…
The quality of human milk shows an association with the women's diet and lifestyle.
Dietary inorganic nitrate supplementation will decrease O2 cost of exercise in patients with mitochondrial myopathy.
Phase I: To investigate whether it is feasible to organise an international multi-centre pragmatic trial to study the value of individualised homeopathic add-on treatment using a semi-standardised algorithm in women with premenstrual disorders,…
Compared to a control group, the mindfulness group intervention is expected to result in: 1. A decrease in symptoms of psychological distress; 2. An increase in quality of life; 3. An increase in heart rate variability; 4. A decrease in blood…
Falls are common in elderly and often result in adverse consequences. The effectiveness of C-Mill training, i.e. treadmill walking with a specific emphasis on functional walking ability via constant and irregular gait modulations, obstacle crossing…
1. Cancer survivors experience more meaning in life after the intervention; 2. Psychological wellbeing in cancer survivors improves after the intervention.
High-dose, weekly erlotinib is a therapeutic option for EGFR-mutated NSCLC patients with leptomeningeal metastases while on EGFR-TKI therapy. In one of the patients treated with this dose schedule not only the leptomeningeal metastases showed…
Yellow fever specific T cells are present in 70% of patients using immunosuppressive medication versus 99% of healthy volunteers.