The hyperfiltration hypothesis implies that children with a solitary functioning kidney are at risk to develop hypertension, (micro)albuminuria and chronic kidney disease. We aim to develop an individualized risk profile for children with a solitary…
ID
Bron
Verkorte titel
Aandoening
- Glomerular hyperfiltration
- Solitary functioning kidney
- Congenital Anomalies of the Kidney and Urinary Tract
- Children
- Chronic Kidney Disease
- Hypertension
- Proteinuria
- Genetics
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Proportion of children with signs of renal injury (hypertension, proteinuria, chronic kidney disease);<br>
2. Genetic malformations (CNV, SNPs).
Achtergrond van het onderzoek
Congenital anomalies of the kidney and urinary tract (CAKUT) are the major cause of end-stage renal disease in childhood. One important subgroup of CAKUT-patients consists of children with solitary functioning kidneys. A solitary functioning kidney from childhood can be of congenital origin or can also be acquired after unilateral nephrectomy. Both types of solitary functioning kidney have been associated with an increased risk to develop chronic kidney disease in later life. This risk may be caused due to glomerular hyperfiltration in the reduced number of nephrons following renal mass reduction, as described by Brenner. No new nephrons can be formed after the 34-36th week of gestation, which implies that glomerular hyperfiltration is present in a solitary functioning kidney. Another significant risk factor in the development of chronic kidney disease is the high prevalence of associated CAKUT found in patients with a solitary functioning kidney. Finally, genetic factors that play a role in renal development have incrementally been identified to underlie the solitary functioning kidney.
THE KIMONO-STUDY aims to develop an individualized risk profile for children with a solitary functioning kidney by performing studies on the development of renal injury, genetics and epidemiologyl.
Doel van het onderzoek
The hyperfiltration hypothesis implies that children with a solitary functioning kidney are at risk to develop hypertension, (micro)albuminuria and chronic kidney disease. We aim to develop an individualized risk profile for children with a solitary functioning kidney based on renal parameters, genetics and epidemiological studies.
Onderzoeksopzet
Cross-sectional studies.
Onderzoeksproduct en/of interventie
1. Gold standard GFR measurement;
2. 24h blood pressure monitoring;
3. Genetical studies (eg NextGen Exome sequencing, Copy Number Variation analysis);
4. Questionaires.
Publiek
VU University Medical Center<br>
P.O. Box 7057
R. Westland
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4443148
r.westland@vumc.nl
Wetenschappelijk
VU University Medical Center<br>
P.O. Box 7057
R. Westland
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4443148
r.westland@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients with an congenital or acquired solitary functioning kidney;
2. Age 0 - 21 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Renal function on DMSA > 10%;
2. A solitary functioning kidney after renal transplant.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3597 |
| NTR-old | NTR3748 |
| Ander register | VUmc : 1101-058 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
Samenvatting resultaten
2. Westland R, Schreuder MF, Bökenkamp A, Spreeuwenburg MD, Wijk JAE van. Nierschade bij kinderen met een mononier – DE KIMONO-STUDIE. Tijdschrift voor Kindergeneeskunde (6 december 2012).<br>
3. Westland R, Wijk JAE van, Schreuder MF. The reason why mother nature provided us with two kidneys: the risks of a congenital solitary functioning kidney. Nephrol Dial Transplant. 2012 Jun;27(6):2603-4. Epub 2011 Nov 5. <br>
4. Westland R, Schreuder MF, Bökenkamp A, Spreeuwenburg MD, Wijk JAE van. Renal injury in children with a solitary functioning kidney - THE KIMONO STUDY. Nephrol Dial Transplant 2011; 26: 1533-1541.<br>
5. Schreuder MF, Westland R, Wijk JAE van. Unilateral multicystic dysplastic kidney: a meta-analysis of observational studies on the incidence associated urinary tract malformations and the contralateral kidney. Nephrol Dial Transplant 2009; 24: 1810-1818.