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The purpose of the activity and heart rate monitor is to measure and track movement (acceleration) and heartbeat, and derive a number of health-related parameters, which can serve as basis for behavioral change programs leading to e.g. a healthier,…
The following hypotheses will be examined: a. patients with multiple sclerosis who become cognitively impaired may experience an increase in pain experience (due to white matter lesions) b. hyperesthesia is known to be predictive of central…
The objectives of this study is to determine The influence of dynamic light conditions on visual function of glaucoma patients.
Current approaches to study and diagnose SVD focus on lesion-detection with MRI. However, SVD-lesions represent an end-stage and are insufficiently specific to understand disease processes. It would be a major advance if SVDs in humans could also be…
1. IBD patients treated with immunosuppressive agents have a diminished anti-pneumococcal antibody response to pneumococcal vaccination. 2. (A) Use of a TNF-alpha inhibitor is associated with a lower antibody response after pneumococcal vaccination…
The objective is to assess whether myocardial microvascular perfusion and myocardial energy metabolism is impaired in HFpEF patients. Additionally we will evaluate whether endothelial dysfunction is associated with diminished myocardial perfusion (e…
Infant formula with different macronutrient profile will result in improved gastrointestinal and stool characteristics
The primary objectives are to determine the optimal pharmacokinetic model of 68Ga-PSMA PET/CT, so 68Ga-PSMA PET/CT results can be quantified in prostate cancer and to determine whether the optimal kinetic model of 68Ga-PSMA PET/CT is valid (by a…
In old age, sufficient protein intake is important to preserve muscle mass and function. Around 50% of older adults (65+ y) consumes ¡Ü1.0 g/kg adjusted body weight (BW)/day (d). There is no rapid method to screen for low protein intake in old age…
To validate the diagnostic performance of the electronic nose, the AeonoseTM, by analysing Volatile Organic Compounds (VOC) patterns in exhaled breath from patients with Mamma Carcinoma (BC) versus controls.
We investigated the associations of maternal folic acid use and folate, vitamin B12 and homocysteine concentrations in early pregnancy with dental development in children. Secondly, we checked whether these associations were modified by MTHFR-C677T…
Exploratory study on the recovery after Achilles Tendon Rupture (ATR)
To investigate the incidence of new-onset AF in patients with coronary artery disease and an impaired LVEF, who will receive a single chamber ICD as primary prevention for sudden cardiac death.
It is hypothesized that the CutaStim electrode will have a higher one week test-retest reliability than the currently used electrodes.
Laparoscopic catheter insertion is better than open catheter insertion for peritoneal dialysis
PSMA-PET/CT is an accurate diagnostic tool in detection of lymph node metastases, with a sensitivity of at least 80%.
This study will investigate whether within BR grade 3 ER/PR+ or HER2+ breast cancers the percentage of homologous recombination deficiency is substantially higher in metastatic lesions compared to primary breast cancers.
We hypothesize that endoscopic mucosal resection using suck-and-snare technique (cap-assisted) is effective and safe for non-lifting or flat benign colorectal lesions