553 resultaten
ADMA (asymmetric dimethylarginine) plasma concentrations are higher in persons with mild renal insufficiency compared to persons with normal kidney function. ADMA plasma concentrations are inversely proportional to renal perfusion and endothelial…
Lithium treatment potentially enhances survival and slows disease progression in ALS patients
The hypothesis is that stratification of the referred population by the two referring screening radiologists using a validated design (BI-RADS, screening variant) can lead to a fast track workflow with only imaging tools, which would enable us to…
Wet-wrap treatment with diluted corticosteroids is more effective than wet-wrap treatment with emollients only
1. Pre- and post-hydration using a sodium bicarbonate infusion scheme is an effective method to prevent CIN from occurring. 2. The current protocol is efficient in identifying high risk patients. 3. Microalbuminuria and microglobulinuria can…
We hypothesise that one year compression therapy after DVT is equally effective as two years in the prevention of the post-thrombotic syndrome - in selected patients.
Primary research question: Is there a difference in effectiveness and costs of clozapine treatment compared to olanzapine treatment in the reduction of substance use disorders of patients with schizophrenia and related psychotic disorders?…
Early lipid and extra amino acid administration is safe and effective and leads to improved short- and long-term outcome.
THC causes changes in resting state brain activity that can be visualized by fMRI
Rimonabant increases the availability of dopamine D2 receptors in the brain's striatal area. This subsequently reduces cocaine craving and decreases relapse in human detoxified cocaine users.
- Internet interventions without coach are less effective than those with a coach - The expected smaller outcomes weigh up to the advantages of a much simpler infrastructure, in clinical and economic outcomes
Renal function improves when converting stable livertransplant patients from cyclosporin to tacrolimus; it also improves with Bayesian C4 monitoring compared to C0 monitoring on tacrolimus.
OTR4120 will improve healing of chronic ulcers.
We hypothesize that expiratory Volatile Organic Compounds analysis by an electronic nose is capable of discriminating between asymptomatic infants and infants with respiratory wheeze.
Interactive website will: 1. Empower WC claimants 2. Enhance insurance physician-patient relationship 3. Increase WC claimant and physician satisfaction 4. Improve WC claimant return-to-work perspective
A possibly competitive inhibition between imatinib and rosuvastatin as substrates for the same solute carriers (i.e. OATP 1A2 and ABCG2) may result in drug-drug interactions and altered pharmacokinetics of imatinib.
Werkzaamheidsdoelstellingen:- Primaire doelstelling: de niet-inferieure werkzaamheid aantonen van PGL4001 t.o.v. de GnRH-agonist om vóór chirurgie hevige uteriene bloedingen door uterusmyomen te verminderen.- Secundaire doelstellingen: aantonen van…
De primaire doelstelling van het onderzoek is om kwantitatief de farmacokinetiek (distributie, metabolisme en excretie) van [14C]bendamustine en metabolieten daarvan te bepalen bij patiënten met bevestigde, recidiverende of refractaire maligniteit (…
Middels dit onderzoek willen wij beoordelen of het beter leren omgaan met vermoeidheid effectief is voor de behandeling van de vermoeidheid en de gezondheidskosten kan verlagen.