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The expectation is that fear of childbirth and additional pain are important reasons for choosing analgesia, or at least influence the choice. An expected reason for not choosing analgesia is that it could be detrimental for the (unborn) child. It…
To test the hypothesis that acetaminophen is a safe and effective analgesia in neonates and to determine the optimal loading dose of intravenous Acetaminophen in neonates of different gestational age subgroups.
The aim of the study is to assess the relation of gingival abrasion to recession in both manual and power brush users. Gingival recession, exposure of the root surface due to apical migration of the gingival margin, affects a significant amount of…
The null hypothesis will be that Caphosol does not decrease the number of days of mucositis > grade 1, whereas the alternative hypothesis is that it will decrease the number of days of mucositis > grade 1 with 50%.
In this study the hypothesis will be tested that gemcitabine has a radiosensitizing effect in addition to 131I-MIBG therapy which will lead to increased anti-tumour effect in neuroblastoma.
The hypothesis is that offering CBT in a group format while discontinuing antidepressant medication will reduce the high relapse rates in remitted anxiety disorder patients who discontinue pharmacological treatment.
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
To investigate whether the clinical outcome is similar after the implantation of the Resolute Integrity stent versus the Promus Element stent (non-inferiority test).
Tropicamide is less effective in inhibiting accommodation and has a small window of maximum activity. Cyclopentolate is more effective but in darker pigmented subjects a significant residual accommodation can be present. Children often show…
Primary objective: Does a 30-minute episode of helium breathing in humans decrease the amount of pro-inflammatory cytokines and chemokines produced in whole blood after immunostimulation ex vivo?
After receiving PST, stroke patients will have a more effective coping style followed by a better quality of life.
The simplified HALO360 ablation regimen result in an easier and faster ablation procedure, while maintaining efficacy and safety.
ICG alone without being absorbed to albumin can be used for near-infrared fluorescence SLNB in breast cancer patients.
A four day adminstration of N-acetylcysteine (3600 mg/day) will reduce craving, withdrawal symptoms and the bias towards nicotine related cues compared to a four day administration of placebo in nicotine dependent subjects.
The observed improvement in palliative care (dyspnoea is the most prominent symptom) in the pleurodesis group is less than the improvement in the indwelling arm.
The primary objective of the REBEL study is to collect data needed to design control policies to diminish the spread of ESBL-producing Gram negative bacteria in the Dutch population.
High-risk human papillomavirus (hr-HPV) DNA testing complementary to current cytology examination (i.e. Pap test) of cervical smears has shown an increased sensitivity and negative predictive value (NPV) for cervical cancer and its precursor lesions…
ARA290 will reduce disease activity in rheumatoid arthritis.
Stepped cased finding of women with increased fracture risk using questionnaires , bone densitometry and vertebral morfometry and treatment with bone sparing drugs of those with indcreased fracture risk in primary care reduces fractures.
It is hypothesised that the use of intra-operative ultrasonography in the excision of palpable breast cancer compared with the standard palpation-guided surgery will improve the ability to spare healthy breast tissue while maintaining or even…