A four day adminstration of N-acetylcysteine (3600 mg/day) will reduce craving, withdrawal symptoms and the bias towards nicotine related cues compared to a four day administration of placebo in nicotine dependent subjects.
ID
Bron
Verkorte titel
Aandoening
nicotine dependence
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Self-reported craving;<br>
2. Self-reported withdrawal symptoms;<br>
3. Neurocognitive tasks.
Achtergrond van het onderzoek
Preclinical studies and human pilot studies have shown reduced drug seeking behavior and craving in substance dependent rats and humans. In the current study, we will investigate whether a four day administration of N-acetylcysteine (3600 mg) will reduce craving and the bias towards nicotine related cues in heavy smokers. Twenty heavy smoking students (>15 sigarettes a day) are recruited for this double blind, randomised cross-over study. During the first week participants will receive either N-acetylcysteine or placebo during 4 days. After a week wash-out period, participants will cross-over to receive NAC or placebo during the last 4 days. During the testing periods, participants will report craving levels and withdrawal symptoms and perform neurocognitive tasks.
Doel van het onderzoek
A four day adminstration of N-acetylcysteine (3600 mg/day) will reduce craving, withdrawal symptoms and the bias towards nicotine related cues compared to a four day administration of placebo in nicotine dependent subjects.
Onderzoeksopzet
1. First week: 4 days administration of either N-acetylcysteine or placebo;
2. Second week: Wash-out period;
3. Third week, cross-over: 4 days administration of either N-acetylcysteine or placebo.
Onderzoeksproduct en/of interventie
1. 4 day administration of 3600 mg of N-acetylcysteine;
2. 4 day administration of placebo.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Undergraduate students;
2. Smoking minimum of 15 sigarettes a day.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Major illnesses;
2. Dependent on any other substance other than nicotine;
3. Currently on medication other than birth control;
4. Pregnant or planning to become pregnant;
5. Ulcers;
6. Color blind.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2086 |
| NTR-old | NTR2204 |
| Ander register | : |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |