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Hypothesis 1: Participants in both conditions (experimental and placebo) will show a reduction in gamble problem severity immediately post-intervention and at 3-and 6-month follow-ups. However, participants in the experimental condition will show a…
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
- Smokers are implicitly biased with regard to the pros/cons of smoking (more attention and/or approach tendencies with regard to the pros) - These biases can be retrained using implicit pictorial trainings based on the Visual Probe Task and the…
A combination therapy (MDT and TESIs) is effective and cost-effective compared to usual care among herniated nucleus pulpos patients with an indication for a lumbar herniated disc surgery
Trends in and variability of vital signs reveal hidden information about the state and deterioration of the patient compared to absolute values of vital signs.
We hypothesize that group medical appointments will enhance adherence to treatment and self-efficacy in patients with sickle cell disease, as well as increase quality of life, and satisfaction with the treating physician and nurse. When performing…
A Community One Health approach (bringing human and animal health together at the community level) improves disease surveillance efforts by Community Health Workers, health knowledge and behavior and physical health in study populations.
We hypothesize that the underlying mechanisms of the varying response in multiple parameters within an individual can be attributed to variability in the causal path between drug administration, drug tissue distribution, and tissue receptor…
Cabazitaxel is a tubulin-binding taxane drug that improves survival of patients with docetaxel-metastatic-castration-resistant prostate cancer (mCRPC). Unfortunately, cabazitaxel is not effective in all patients and can have serious side effects.…
The Untire app will create awareness by proving psycho-education and will give insight in ones’ energy levels, ones’ thoughts and behaviors in relation to energy levels and provides exercises that help users to challenge ineffective thoughts and…
Casein ingested within a normal milk matrix results in a more rapid digestion and amino acid absorption, resulting in greater amino acid availability and post-prandial muscle protein accretion as compared to the ingestion of isolated casein (…
The addition of fluorescence imaging to the standard radio-guided procedure improves intraoperative sentinel node detection.
We hypothesize this difference is due to differences in the mechanisms by which the individuals can withstand and/or adapt to the stress conditions applied in the clinical model and that these mechanisms are of key importance in our ability to…
We believe that by engaging the target group in the process of intervention development, more effective intervention targeting children’s physical activity and dietary behaviors can be developed.
This overall study aims to evaluate the effects of cardiology PC+ centre on the Triple Aim outcomes. The underlying premises of the researchers on the effects of the intervention are that the cardiology PC+ centre will result in an (at least)…
The manual knee-rotation-test in 90 degree flection is reliable
Our primary outcome is to change knowledge, attitude and managing skills of prison staff. We hypothesis that the elearning module will contribute to improve knowledge, attitude and skills
To investigate the possibility to predict chemotherapy response using proliferation assays.
With help of the TOF watch, a reduction in muscle relaxation can be observed earlier. In this way, peroperative events (pain or contractions by the patient) can be prevented. Less peroperative events lead to less postoperative pain.
A proportion of patients with juvenile idiopathic arthritis with minimal disease activity can remain in a state of minimal disease activity with a lower dose of etanercept than the standard dose or even without etanercept.