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To study the effect of the interaction of cyclooxygenase-2 (COX-2) inhibition (started preoperatively and continued 5 days into the postoperative period) and extended local anaesthetic blockade via paravertebral block on postoperative central…
Non-inferiority (defined as < 12.5% increase) of pooled buffy coat-derived PR platelet concentrates (PR-plasma-PCs) compared to plasma (plasma-PCs) in terms of clinical efficacy determined by WHO grade ≥ 2 bleeding complications.
In line with results from recent pharmacological studies, it is expected that: 1. Inhibiting the cholinergic system by Inversine (Mecamylamine Hydrochloride) results in an impairment of disengagement, but will not affect bias; 2. Inhibiting the…
The primary objective is to demonstrate the non-inferiority of bevacizumab to ranibizumab in the treatment of patients with subfoveal CNV secondary to AMD as determined by the change in best-corrected visual acuity in the study eye from baseline to…
Suppression of SWS, without changing total sleep time, may affect total energy expenditure (TEE), activity induced energy expenditure (AEE), non-exercise activity thermogenesis (NEAT), endocrinological parameters and energy intake.
Is docetaxel weekly as effective and less toxic than the same dose given 3-weekly.
It is expected that the new pre-thickened sip feed is as safe as and well-tolerated as standard sip feed thickened with a commercially available thickener.
The investigational anti-reflux formula will be equivalent to the currently marketed control anti-reflux formula with regard to intestinal tolerance during eight weeks in infants with regurgitation.
The healing of donor site wounds after split-skin grafting can be promoted by the use of one of five specific wound dressing materials as compared in this trial.
1. The effect of cognitive behavioral therapy in internettherapy and face-to-face therapy is larger then without therapy on women with a sexual dysfuntion; 2. The impact of Internet therapy is just as large as the impact of treatment-as-usual (face-…
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Dietary management of nutrient deficiencies with the medical food under study has a positive effect on cognitive performance in patients with prodromal Alzheimer's Disease.
Activation of SIRT1 (silent information regulator transcript) results in inhibition of inflammation in humans.
The effect of stepping down asthma therapy in clinically stable children on exercise induced asthma.
We hypothesized that in a subgroup of patients EIBH would improve after the cessation of LABA.
In the original study (NTR215), we assessed the 3-year risk of CIN3+ in women stratified for hrHPV and cytology at baseline. In this study, we will assess the 5-year risks. Stratification at baseline is done on hrHPV, cytology, and hrHPV genotype.…
Hearing aid fitting will reduce the tinnitus burden in patients with mild hearing loss.
1. In Barrett Esophagus (BE), probe-based laser endomicroscopy (pCLE) provides better correlation with the histological diagnosis compared to detailed inspection with Narrow Band Imaging (NBI), reducing the high rate of false-positive findings with…
This study was therefore designed to determine whether cinnamon lower postprandial blood glucose, and insulin levels in subjects with type 2 diabetes or impaired glucose tolerance.
The COL3A1 polymorphism is a inheritable genetic defect, responsible for the increased susceptibility to pelvic organ prolapse in women.
1. Prosthetic valve characteristics (type; location; size resulting in the presence/absence of PPM) are related to functional outcome and quality of life; 2. The incidence/spectrum of prosthetic valve-related complications in adults with CHD differs…