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The infusion of intrathecal baclofen using higher flow rates results in more extensive intrathecal distribution, hence benefits pharmacodynamic properties of baclofen
The primary objective is to investigate to what extent early IVIG treatment in children with newly diagnosed acute ITP reduces the risk of development of chronic disease. Secondary objectives are: 1. To estimate the alteration in the clinical…
Comparison of progression free survival (PFS) in elderly patients with advanced CRC treated first line by tegafur-uracil plus LV or capecitabine. It is considered that, in this patient population, only differences in the median time to progression…
THC causes changes in resting state brain activity that can be visualized by fMRI
COPCA (Coping and Caring) intervention in infants at high risk for cerebral palsy will result in better functioning than Tradional Paediatric Therapy.
In lungcancer bone metastases appear frequently en they are an important cause of pain. The expectation is that Bondronat® gives a fast pain reduction. In this phase II study will be examined whether this fast pain reduction indeed occurs and if…
In this study we will compare three method to assess the magnitude of the ventilatory response; our hypothesis is that different methods will yield different results.
ADMA (asymmetric dimethylarginine) plasma concentrations are higher in persons with mild renal insufficiency compared to persons with normal kidney function. ADMA plasma concentrations are inversely proportional to renal perfusion and endothelial…
To compare the clinical and cost-effectiveness of pelvic floor muscle training versus TVT/TVT-O surgery as primary treatment of moderate to severe female urinary incontinence.
Large head metal-on-metal arthroplasties show less bone mass density loss (DEXA)and higher serum metal ion concentrations. We expect equal functional scores, greater range of motion, less dislocations, fewer periprosthetic radiolucencies and…
Increased and improved mastication will improve (or, slow down the loss of) cognition, mood and circadian rhythm of elderly people suffering from dementia.
Renal function improves when converting stable livertransplant patients from cyclosporin to tacrolimus; it also improves with Bayesian C4 monitoring compared to C0 monitoring on tacrolimus.
In patients with non-insulin dependent type 2 diabetes, intensive, short term physical activity is associated with decreased blood glucose levels and number of cardiovascular complications. In patients who are insulin dependent however, the effects…
Hypothesis is that elderly patients, acutely admitted for hip fracture, treated with melatonin for 5 days will experience less delirium than patients treated with placebo.
We postulate that exhaled breath sampling by an electronic nose can distinguish and adequately identify smell-prints from: 1. Atopic patients without airway obstruction 2. Non-atopic patients without airway obstruction 3. Atopic patients with…
The correlation between alcohol intake and dehydration is observed in several studies. ORS, Oral Rehydration Solution is a reliable treatment for dehydration. The link between ORS and relieve of veisalgia has been suggested by several sources,…
We hypothesize that oral glucose intake and consequently the endogenous induced hyperinsulinemia will lead to insulin-induced microvascular dilatation in healthy normotensive subjects. Furthermore, we suggest that the insulin-mediated microvascular…
A 7-day course of antibiotic treatment is non-inferior to a 14-day course in febrile urinary tract infection.