177 resultaten
Obesity is a growing world wide problem. In The Netherlands, about 10% of all men and women have a BMI of 30 kg/m2 or more. Obesity is a chronic, uncurable metabolic disorder, which is characterised by excessive fatstorage at unfavorable places.…
A first hypothesis is that an advanced quality improvement program (AQIP) significantly improves clinical outcomes in persons with type 2 diabetes compared to a usual quality improvement program (UQIP). The second hypothesis is that persons with…
To evaluate the cost-effectiveness of therapies for male subfertility.
We hypothesize that membrane-residing gangliosides are elevated in obese insulin resistant subjects and correlate to peripheral insulin resistance. Furthermore, we hypothesize that the perturbation of the insulin signaling cascade by elevated…
We hypothesize that children who will follow this structured functional PRE strength training program will increase in muscle strength, which accordingly will lead to functional improvement in physical functioning, but with no negative effect…
The objective of this study is to investigate whether thoracic radiotherapy can improve 1year survival in …
Since bleeding risk is high in the elderly we hypothesize that clopidogrel is superior to ticagrelor and prasugrel in terms of causing lesser bleeding events and being non inferior in net clinical benefit in patients above 75 years and CRUSADE…
Supplementation with omega-3 LCPUFA from krill oil in healthy adolescents will result in: - improvement of the omega-3 index - improved cognitive performance - improved mental well-being - better academic achievement
Wet-wrap treatment with diluted corticosteroids is more effective than wet-wrap treatment with emollients only
Information on the dynamics and shape of the device and how these change over time will improve our understanding about the fixation and/or sealing of the device, which may help in stent selection and in designing stent grafts that are more durable.
We hypothesized that FFA loading could impair mitochondrial function and that the potency of FFA to disturb mitochondrial function and glucose uptake would depend on the degree of desaturation of the fatty acids infused.
Child maltreatment is a major social problem with many adverse consequences. A substantial number of maltreated children is not identified by health care professionals. To improve identification of maltreated children in hospitals, a new hospital-…
With usage of mesh material (Avaulta anterior) in the treatment of a cystocele >/ 2 with complaints a better anatomical result is achieved in comparence with the standard treatment (anterior colporraphy).
To reduce treatment-related toxicity in patients with localized prostate cancer, focal treatment is warranted. This can be achieved with MRI guided high-dose-rate brachytherapy. We expect that a single dose of 19 Gy to the tumour volume will be of…
ORIF with volar fixed-angle plates and external fixation have a similar outcome as measured with the DASH score (and the Mayor Wrist Score).
1. Active sniffing decreases appetite; 2. Food choice is mainly influenced by the food odour that was perceived first.
A physical reactivation program is more effective in improving physical activity behaviour, quality of life, diabetic parameters and psychosocial well being than usual care in type-2 diabetic patients.
A low peak E2 during COS is considered to be safer than a high peak E2 in women with breast cancer
To find out if intravenous MSC is a safe treatment for children with therapy-resistant JIA