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A first hypothesis is that an advanced quality improvement program (AQIP) significantly improves clinical outcomes in persons with type 2 diabetes compared to a usual quality improvement program (UQIP). The second hypothesis is that persons with…
Recent research shows that obesity is associated with changed bowel flora composition with a relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Interestingly, this specific bacteria associated condition…
In the first 6 months Liraglutide affects weight more than CBT, but CBT provides weight maintenance after 12 months.
1. The primary research inquiry being raised concerns anaesthesia related causes: Is it possible that adapting an amount of Sevoflurane, from 1 MAC (minimum alveolar concentration) (2,5 vol%) to ½ MAC (1,25 vol%) in an MRI scan can reduce the…
Publishing a guideline is not enough. An implementation strategy is needed to improve pain reporting, pain measurement and adequate pain therapy.
Higher occlusion rate in the EVLA group seen at 1 week postoperative. More recurrences seen in the VNUS group seen at long term. No differences in short term recovery results between both groups.
We hypothesize that membrane-residing gangliosides are elevated in obese insulin resistant subjects and correlate to peripheral insulin resistance. Furthermore, we hypothesize that the perturbation of the insulin signaling cascade by elevated…
We hypothesize that children who will follow this structured functional PRE strength training program will increase in muscle strength, which accordingly will lead to functional improvement in physical functioning, but with no negative effect…
The objective of this study is to investigate whether thoracic radiotherapy can improve 1year survival in …
Clinically, children with syndromic craniosynostosis seem to have an increased risk of learning disabilities and behavioral problems in comparison with the general population.
The OptiScanner provides accurate blood glucose levels in critically ill patients.
1. Volume intervention by a diuretic and moderate sodium diet potentiates the antiproteinuric effects of aliskiren in patients with residual albuminuria during conventional RAAS-blockade; 2. Aliskiren neutralizes the reactive rise in plasma renin…
Chronic Obstructive Pulmonary Disease (COPD) is a chronic, progressive lung disease. The prevalence and associated costs of COPD are projected to increase the upcoming decades. The treatment of COPD aims to reduce risk factors, prevent disease…
Diskus is superior to Elpenhaler with regard to ease of use, preference and satisfaction.
The addition of metronomic cyclophosphamide to standard 2nd line treatment with everolimus will improve progression free survival of patients at 4 months from the reported value of 50% to 70% in patients with mRCC.
Wet-wrap treatment with diluted corticosteroids is more effective than wet-wrap treatment with emollients only
In RA patients that achieved disease remission by treatment with the combination of a csDMARD and anti-TNF, there is a difference in (cost-)effectiveness when medication is tapered according to strategy A (csDMARD first) compared to strategy B (anti…
Our hypothesis is that reverse arthroplasty has a better functional outcome and patient satisfaction than hemi-arthoplasty in patients with a three or four part proximal humerus fracture.
We hypothesized that FFA loading could impair mitochondrial function and that the potency of FFA to disturb mitochondrial function and glucose uptake would depend on the degree of desaturation of the fatty acids infused.
Postpartum urinary retention (PUR) is a complication with a varying prevalence, from 0.5 - 18%. For asymptomatic PUR, i.e. the ability to void but with a post residual volume (PVRV) of ≥150 ml, the estimation of prevalence is between 10-45%.…