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RhDNase can liquefy mucus in children with an atelectasis during mechanical ventilation, resulting in improved mucociliary clearance, less mucus retention and less airways obstruction, thereby enhancing the rate of resolution of an atelectasis.…
One cycle of IVF-eSET followed by transfer of frozen embryos is at least as effective as three cycles of IUI-COH in terms of ongoing pregnancy. Multiple pregnancies however can largely be prevented by treating women with IVF-eSET.
The Rotterdam Daily Exercise Project leads to less overweight, improved fitness, healthier food habits and healthier exercise habits.
Antisense oligoribonucleotides inducing exon skipping is a promising approach to restore dystrophin synthesis in patients with Duchenne.
Athletes with longstanding groin pain recover faster and more completely if they are treated with specific pelvic stabilizing muscle training compared with regular care.
The hypothesis to be tested is that the outcome in arm B is better than in arm A.
Correction of sub-clinical prolongation of coagulation tests (i.e., PTT between 14.7 – 20 seconds and platelets < 100 x 109/L) and transfusion of platelets in patients with Ascal®, significantly decreases the incidence of clinical significant…
In the RIO study programme, the efficacy of rimonabant was examined. The next step is to assess the use of rimonabant, its safety and effectiveness in daily practice. In daily practice people also have other diseases, may use other medication and…
The intervention lead to: 1. More knowledge about (the use of) prescribed medicines; 2. A better use of medicines during the stay in the hospital and after discharge.
To compare the efficacy of maintenance therapy with an equal monthly dose of imiglucerase when administered at a frequency of once every four weeks versus once every one or two weeks, in adult type I Gaucher disease patients in stable and good…
Measurement of airways hyperresponsiveness by mannitol (Aridol©) as compared to methacholine saves time to the lung function technician, while being as sensitive to discern hyperresponsive from normo-responsive, and being at least equally acceptable…
Adherence to diabetes guideines is moderate, especially on educational aspects. Changes in lifestyle is a major element of the patient treatment. Studies on motivational Interviewing show promising results among dieticians. There are no primary care…
Based on systematic reviews concerning effective treatments in children with migraine a medical treatment (propanolol) as well as a non-medical treatment (relaxation therapy) appear to be effective compared to no treatment or placebo. however their…
Aetiology of late-onset depressive spectrum disorders may be different from the aetiology of early-onset depression. Concordant with the supposed aetiology of dementia, it has been postulated that chronic low grade immune activation plays a role in…
Many employees who are sicklisted do not really know how to handle the situation. Simple and specific education and individually based instructions through a website can possibly solve or reduce this problem. Besides, the website contains a…
Several open-label pilot studies have shown a promising effect of intrapyloric botulinum toxin injection on symptoms in severe gastroparesis. However, data from randomized, double-blind, placebo-controlled studies are not yet available. We intend to…
Heart rate variability measures correlate with pain intensity in patients with advanced cancer.
Treatment with pregabalin (150-600 mg dose) results in a statistically significant improvement in endpoint mean pain score of ¡Ý 1,2 during 8 weeks follow-up relatively to treatment with placebo.
1. ICVAD removal, followed by six months of silicone gel sheet use, will result in a scar width within the normal range, and normal scar structure, and thus will be superior to two months of silicone gel sheets and no gel sheets; 2. A smaller and/…
Mechanical bowel preparation (MBP) is common practice in elective colorectal surgery. In recent literature the value of MBP is subject of discussion. This non-inferiority, randomized study evaluates the value of MBP before colorectal surgery.