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Drinking Less, Self help for Problem Drinking: randomised clinical trial.

To test the effectiveness of a self help booklet without therapist guidance vis-à-vis a psycho-education brochure for adult problem drinkers in the general population.

Immunity induced by yellow fever vaccination in the elderly (60yrs or older)traveller

The induction of immunity might be slower in older persons than in younger individuals. This could influence the occurence of adverse events induced by the vaccine.

The effect of Beta-Adrenergic receptor blockade on sympathetic activity and Coagulation in patients with Heart failure (BACH-F study).

Sympatho-adrenergic and hypercoagulable activity are enhanced in patients with chronic heart failure, partially mediated by common functional beta2-adrenergic receptor polymorphisms. Non-selective beta-blockers down regulate sympathetic activation…

Laparoscopic ileocolic resection versus infliximab treatment of recurrent distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial).

Laparoscopic ileocolic resection may be more effective than infliximab treatment in recurrent Crohn´s disease located in the terminal ileum improving quality of life and reducing costs.

Transjugular Intrahepatic Porto-systemic Shunt (TIPS) with Gore-tex(R) covered stent-graft versus endoscopic treatment for secondary prevention of gastro-esophageal variceal bleeding.

TIPS using covered stents will be equally or more effective, cost-effective and safe as/than endoscopic treatment in the secondary prevention of gastro-esophageal variceal bleeding.

Intravenous versus subcutaneous immunoglobuline therapy in multifocal motor neuropathy

Subcutaneous immunoglobuline therapy is as effective as intravenous immunoglobuline therapy in maintaining muscle strength in patients with multifocal motor neuropathy

The pharmacokinetics of nimodipine, intravenous and orally, in patients with subarachnoidal hemorrhage admitted in the intensive care.

Describing the pharmacokinetics of nimodipine, especially the variability of bio-availability orally administred nimdipine.

Gerandomiseerde trial naar kosteneffectiviteit van collaborative stepped care bij angststoornissen in de eerste lijn.

Collaborative stepped care for anxiety disorders in primary care is cost effective compared with Care As Usual.

Automatic Weaning Using
Adaptive Support Ventilation (ASV) –
Effect of an Early Weaning Protocol on Time till Extubation of Post–Coronary Artery Bypass Surgery Patients.

We hypothesize time till extubation of post–CABG patients can be shortened by using an early weaning protocol with ASV.

A double blind placebo controlled study on the effect of cerivastatin on the process of atherosclerosis in non-insulin dependent diabetes mellitus (type 2).

To assess the effect of statin therapy on the process of atherosclerosis in type 2 diabetes without manifest cardiovascular disease.

Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery.

The general objective of the DECREASE-IV trial is to assess the clinical efficacy of beta-blocker therapy, statin therapy and combination therapy with beta-blockers and statins in patients undergoing major noncardiac surgery.

A Randomised, Double-blind, Controlled Study on the Effect of One Year Administration of a Nutritional Concept on Immunological Status in HIV-1 Positive Adults not on Antiretroviral Therapy

Improving the immunological status of HIV-1 infected adults not on antiretroviral therapy through nutritional support.

An international, multicenter prospective single arm study to investigate procedural, clinical and angiographic outcomes using the Taxus Liberte stent, with improved side branch access, following the provisional side branch T-stenting approach, in patients with complex lesions.

The purpose of the Liberté One study is to assess procedural, clinical and angiographic outcomes of the provisional T-stenting approach with the Taxus Liberte stent implanted in complex lesions (with side branch involvement). The Taxus Liberte stent…

Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS).

Thrombus aspiration compared to balloon angioplasty will improve myocardial reperfusion during primary percutaneous coronary intervention.

Postoperative flow prediction after creation of a vasculair access for hemodialysis with the aid of a computer simulation model.

It is generally accepted that the early-postoperative flow increase is indicative for successful maturation of an autologous arteriovenous fistula. Our hypothesis is that a patient-specific computer simulation model should be able to predict this…

Analyzes of pathogen and host determinants in hospitalized patients with a laboratory confirmed infection caused by Staphylococcus aureus: the PATHOS Study.

To identify candidate antigens for the development of a prophylactic Staphylococcus aureus vaccine by studying expression profiles of host and pathogen determinants during natural infection.

TIP-glucocorticoids research UMCU rheumatology; Cardiovascular risk factors and insulin resistency in reumatoid arthritis patients with and without glucocorticoids.

What is the relation between disease activity, treatment, and metabolic syndrome / insulin resistance.

Prevention of multiple pregnancies in couples with unexplained or mild male subfertility

Multiple pregancies can be prevented without loss of pregnancy rates by treating couples with manipulated natural cycle IVF or with IVF-eSET plus cryo-cycles instead of standard treatment with intra-uterine insemination and controlled ovarian…

Observational study;
Pilot study assessing sildenafil effect on lung tumour blood flow.

Does sildenafil improve tumour perfusion?

Monitoring of exhaled nitric oxide (FENO) to tailor the lowest effective dose of oral corticosteroids in severe asthma (MONOSA-Study).

1. Daily home monitoring of exhaled nitric oxide (FENO) in patients with severe asthma facilitate tapering of oral corticosteroids to the lowest possible dose, leading to a reduction of total corticosteroid consumption; 2. This can be achieved…