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Activation of SIRT1 (silent information regulator transcript) results in inhibition of inflammation in humans.
We hypothesize that 1) fasting duration may affect the central serotonin and dopamine systems, either centrally or indirectly through effects on peripheral input to the central nervous system, and 2) the effect of fasting may be changed in obesity.
The purpose of the study is to investigate whether we can ameliorate (associative) learning processes in children with ADHD by training working memory. We predict that children in the active working memory training condition will show improved…
In the original study (NTR215), we assessed the 3-year risk of CIN3+ in women stratified for hrHPV and cytology at baseline. In this study, we will assess the 5-year risks. Stratification at baseline is done on hrHPV, cytology, and hrHPV genotype.…
The implicit training (AAT) added to standard behaviour therapy will reduce relapse rates after treatment when compared to the control group.
We hypothesize that the epigenetic changes that are related to childhood trauma provide a treatment target for succesful treatment with SAMe of persistent depression in bipolar disorder
1. What is the effect of information about tobacco additives for smokers and non-smokers? 2. Do participants visit and read all the information which is available on the website?
To assess the effect of statin therapy on the process of atherosclerosis in type 2 diabetes without manifest cardiovascular disease.
Subjects in the PCD-04 arm will show less anthracyclin-induced cardiotoxicty then subjects in the placebo arm.
This study was therefore designed to determine whether cinnamon lower postprandial blood glucose, and insulin levels in subjects with type 2 diabetes or impaired glucose tolerance.
We hypothesize that MTX and LEF combination therapy is superior to MTX monotherapy in patients with psoriatic arthritis
The hypothesis is that testosterone supplementation improves functional mobility, quality of life, body composition, cognitive function, aortic stiffness and cardiovascular risk factors, and bone mineral density compared to placebo.
Based on the human milk composition, Nutricia Research has developed a new infant formula with a new fat blend, more similar to that of human milk. This new formula is currently being studied for safety and its effects on growth. The comparator used…
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
AN-PEP helps to digest gluten in vivo.
RhDNase can liquefy mucus in children with an atelectasis during mechanical ventilation, resulting in improved mucociliary clearance, less mucus retention and less airways obstruction, thereby enhancing the rate of resolution of an atelectasis.…
Statin-treatment has been shown to normalize the learning- and attention deficits in NF1 +/- mice by decreasing Ras activity. The fact that statins are effective in NF1 mice, combined with their very good safety profile, makes them an ideal…
Acclydine is a plant sourced alkaloid which has effects on protein structure and metabolism. In particular it leads to the activation of the pituitary to increase release of growth hormone. The GH axis has been shown to be disturbed in CFS, so this…
The simplified HALO360 ablation regimen result in an easier and faster ablation procedure, while maintaining efficacy and safety.
We hypothesize that consumption of mixtures of 400 grams vegetables and/or fruits for 2 weeks will result in lower ex-vivo induced oxidative DNA damage, increased antioxidant capacity of blood plasma, reduced levels of reactive oxygen species in…