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The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…
The goal of this study is to identify and validate recently discovered and novel biomarkers of pathophysiology, diagnosis, classification, disease activity, prognosis, treatment susceptibility, and treatment efficacy in chronic inflammatory…
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Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.
The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.
A subset of rheumatoid arthritis (RA) patients harbour antibodies against several post-translational modifications and are frequently positive for rheumatoid factor. The exact pathophysiology of the development of the autoantibody response and of RA…
SARS-CoV-2 is present in the cerebrospinal fluid of COVID-19 patients with acute respiratory failure
Treatment with chloroquine or hydroxychloroquine of adult patients admitted with moderate to severe COVID-19, a NEWS-2 score ≤5, reduces the proportion of patients who show progression of their disease defined as a NEWS-2 score ≥ 7(22), admission to…
The aim of this study is to assess whether the use of the IncoSense Smart leads to improvement in efficiency of incontinence care, better quality of life of the clients and reduction of the cost.
A disease control of 60% is expected and will be clinically relevant with a lower reference bound of 45%.
It was hypothesized that comparing the course of uveitis of individual eyes with respect to inflammatory activity and visual acuity (VA), and the impact of particular therapies, to already available data about course and outcome from other patients…
Primary objective: To assess the efficacy of thromboprophylaxis with high prophylactic dose LMWH as compared with standard care without systemic thromboprophylaxis in children treated for primary ALL. Secondary objectives: 1. To assess the safety…
Hemiarthroplasty will result in higher Constant scores (reflecting better functional outcome with less pain) at 1 year compared with non-operative treatment of complex humeral fractures in the elderly.
rt-PA administration by retinal branch vein way in CRVO patients improves final BCVA.
We hypothesize that FMT from a healthy donor will modulate the microbiome of the pouch of patients with ulcerative colitis, and will thereby resolve the inflammation of the pouch.
Based on the results obtained in our previous study (Ruiter, Kolk, Rietveld, Dijkstra & Lotgering, 2011), we hypothesise that: - The experimental changes to the scenarios and new quantitative scoring procedure of the Amsterdam-Nijmegen…
To determine whether a second dose of IVIg in GBS patients with a poor prognosis improves functional outcome after 4 weeks. Secondary outcomes include functional outcome after 8, 12 and 26 weeks, duration of mechanical ventilation, length of…
We hypothesize that higher EC within the FPN is a predictor of better EF. Furthermore, we hypothesize that multilayer centrality is a better predictor of EF than monolayer centrality.
Because the aim of this observational study is to obtain insight in the nutrient and fluid intake, and nutrient and biomarker concentrations in the blood in patients with ischemic stroke, the focus will be on descriptive statistics and there will be…
The aim of this study is to compare the efficacy of EBRT versus SEMS insertion for palliation of dysphagia symptoms in patients with esophageal cancer