435 resultaten
1. Verbeteren van de overleving in vergelijking met de eerdere protocollen van de SKION, in het bijzonder ALL-9 and ALL-10. Doelstelling is om therapie te verminderen voor een deel van de patiënten (TEL/AML1, Down syndroom, geïsoleerd slechte…
Patients with a BMI > 30 kg/m2 in the ICU have a higher incidence of pressure ulcers and wound infections in the ICU compared with patients with a BMI 18-25kg/m2. They develop them sooner during admittance and the severity and time to…
We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…
1. Curative treatment of primary metastasized rectal cancer includes resection of primary tumor and metastases; 2. Primary tumors in case of metastasized disease are often locally advanced and need downsizing before resection; 3. Systemic treatment…
Bilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production.
1. Vascular inflammation becomes activated several days to weeks before an acute coronary syndrome; 2. Biomarkers of vascular inflammation, distorted lipid metabolism, endothelial dysfunction, diminished endothelial regenerative capacity,…
Primary Objective: The goal of this pilot study is to evaluate whether optical spectroscopy is able to differentiate between nerve tissue and surrounding tissue. Secondary Objective: During the measurement procedure, possible improvements of the…
Preclinical and clinical studies have shown that adoptive therapy with T cell receptor reactive lymphocytes leads to a clinical response in 13-45% of the patients.
This pilot study hypothesizes that folate-FITC enhanced fluorescence imaging enables the intra-operative detection of breast carcinoma in breast cancer patients.
A new generation hydrophobic acrylic polymer, the GF® raw material (Physiol) equilibrated in saline solution prior to implantation combines the benefits of two families of IOL materials, i.e., hydrophobic and hydrophilic acrylic materials (…
1. The in vitro immunological reactivity is higher in adolescence compared to adjacent age categories which leads to a higher risk of rejection of the transplanted kidney; 2. More naïve T-cells are present in the circulation in adolescence compared…
Two hypotheses will be tested. First, we expect differential susceptibility, which means that children in the intervention condition who carry one or more susceptibility genes (i.e., carrying a MAOA low activity (short) allele; DAT 10-repeat allele…
Differentiated thyroid carcinoma (DTC) is rare during childhood. Children often present with a more advanced tumor stage compared to adults. Nevertheless, the prognosis is excellent. Data about long-term effects of treatment in pediatric DTC…
Vaccination against pneumococcal bacteria results in eradication of nasopharyngeal colonization by pneumococcal serotypes present in the pneumococcal vaccine in vaccinated children and their parents but serotypes not included in the vaccine fill in…
The objective of this study is to determine whether retention of cerclage after PPROM reduces chorioamnionitis, improves latency (without a significant increase in chorioamnionitis), and lessens neonatal morbidity.
The QST battery of the DFNS (Rolke 2006) is a comprehensive measurement for neurosensory function. The current study is a phase 0 study to assess the repeatability of the QST battery of the DFNS and the intra-dermal capsaicin model.
Placement of this stent will achieve good technical and clinical success rates, that are at least comparable to previously reported results of studies with other stent-designs. Moreover a low re-obstruction rate is expected due to the new stent…
A significant difference in angular measurement is expected in weightbearing and non-weightbearing radiographs in patients with hallux valgus deformity.
Dihydropyrimidine Dehydrogenase (DPD) is the initial and rate-limiting enzyme in the metabolism of 5-fluorouracil (5-FU). Patients with a partial or complete DPD deficiency are at risk to develop severe toxicity after 5-FU administration. Uracil is…
COMT and/or PRODH polymorphisms are debt to cognitive deterioration in velocardiofacial syndrome.