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We hypothesize that there is no difference in clinical and radiological outcome when using PSG for UKA compared with results from the literature describing results from conventional UKA surgical techniques.
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
Trends in and variability of vital signs reveal hidden information about the state and deterioration of the patient compared to absolute values of vital signs.
Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
To evaluate the anti-inflammatory effects of 3 months statin therapy on vessel wall inflammation by means of FDG PET/CT in patients with CKD.
An early mobilization program in critically ill children reduce the consumption of sedatives and opioids and the prevalence of delirium.
A conservative approach, rather than surgical resection, is safe for non-functioning grade 1 and 2 pancreatic neuroendocrine tumors <2cm.
- brain activation and connectivity during emotion regulation, thinking about future events, inferring on emotions of others and rest are different in patients with a recent suicide attempt compared to patient controls and healthy controls - brain…
1. The predictive biomarkers for tumor response to immuno modulating therapy will be a combination of adaptive and innate immune status per patient that will be estimated with a tumor biopsy before, 6 weeks after start treatment (optional) and at…
This study will evaluate the effectiveness of IPAS, with and without additional support, to improve objectively measured PA levels. We expect that IPAS will raise the level of PA more than normal care (UC) with a higher expected effect for IPAS +…
The main objective is to investigate whether actigraphy can be used as an objective measure to designate the presence or severity of apathy in patients with schizophrenia. To this end, we will measure activity levels using an accelerometer (i.e.…
The overall hypothesis is that the developed exercise therapy program is feasible, safe and improves cardiorespiratory fitness, functional performance, reduces CV risk factors and disease activity in patients with RA and high CV risk.
The aim of this study is to evaluate whether consulting a sexologist will have better outcomes considering quality of life and sexual function in women who underwent surgical treatment for (pre)malignant vulvar lesions.
There is no formal statistical hypothesis to be tested in this Registry program.
WSI can equally to Conventional Light Microscopy (CLM) be used in primary diagnosics of cervical cytological thin-layer slides
Preterm infants often require supplemental oxygen to prevent hypoxemia and hyperoxemia. Conditions that have been associated with organ damage and an increased mortality. Newly developed techniques incorporated in the ventilator provide the…
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