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Parametric cochlear implant map adjustment by implant recipients.

Speech understanding with a speech processor fitted using the parametric fitting procedure and the recipient's own fine-tuning is as good as with a conventional fitting. The parametric fitting is more patient friendly and less time-consuming.

A phase II study of up-front red blood cell transfusion followed by maintenance Erythropoetin-alpha (Epo-alpha) s.c. support during chemotherapy of solid tumors.

An upfront RBCT aiming at low-normal Hb levels will ameliorate anemia-caused tumor hypoxia-related resistance to chemotherapy before the start of chemotherapy and may decrease secondary anemia-induced endogenous release of cytokines like VEGF,…

The implementation of microarrays in cancer diagnosis (Microarray prognostics in breast cancer).

Hypothesis: The implementation of microarray diagnostics is feasible in general practice in community hospitals.

Bordetella pertussis serology in pregnancy.

About 6% of the population between 3 and 79 years suffers each year of a B.pertussis infection, also pregnant women. These women are a source of infection for their newborn babies.

Testosterone, aging and cognitive functioning.

Serum testosterone levels in men will be related to basic cognitive functions, such as mental processing speed and cognitive control.

5-ASA-AZA study.

5-Aminosalicylates influence the metabolism of thiopurines leading to higher levels of the pharmacological end-metabolite 6-thioguaninenucleotides.

A longitudinal non-invasive study of changes in urinary bladder contractility secondary to benign prostatic hyperplasia.

N/A

Delirium treatment at the geriatric ward (DELTa G)
Treatment of delirium: rivastigmine or haloperidol as primary treatment for delirium in delirious patients on a geriatric ward.
A randomized placebo-controlled study.

Rivastigmine is as effective as haloperidol in the treatment of a delirium.

Comparison of short course cyclophosphamide followed by mycophenolate mofetil versus long course cyclophosphamide in the treatment of proliferative lupus nephritis.

Short course cyclophosphamide followed by mycophenolate mofetil will reduce renal relapses to 33% (vs 10% in patients treated with long-course cyclophosphamide).

Delirium treatment at the surgical ward (DELTa S)
Treatment of delirium: rivastigmine or haloperidol as primary treatment for delirium in elderly patients with a fractured hip.
A randomized placebo-controlled study.

Rivastigmine is as effective in the treatment of delirium as Haloperidol.

Joint distraction in the treatment of knee osteoarthritis: efficacy and underlying mechanisms.

A two month distraction period results in similar clinical beneficial effects as a three month distraction period.

Implementation of evidence-based guidelines for appropriate use of ultrasonography in diagnostic breast imaging: the MAMMOED-2 study.

1. To develop (cost-) effective implementation strategies which are feasible in daily practice; 2. To test the guidelines in a multicentre effectiveness trial; 3. To develop general quality indicators with appropriate measuring tools for diagnostic…

A Phase II study to investigate the effect of Glivec® (imatinib mesylate, formerly known as STI571) in patients with inoperable medullary thyroid carcinoma.

In the pathogenesis of medullary thyroid carcinoma a mutation of the RET thyrosine kinase system plays an essential role. In animal models the thyrosine kinase inhibitor imatinib showed tumor regression. So a Phase-2 study in patients with…

Multislice computed tomography coronary angiography in patients with stable and unstable angina: a multicenter study.

Is diagnostic non-invasive coronary angiography with MS-CT a cost-effective alternative to diagnostic invasive coronary angiography in the management of patients with stable and unstable angina pectoris, referred for evaluation of the presence of…

Ibopamine 2% eyedrops in the treatment of patients with ocular hypotony after vitreoretinal surgery for retinal detachment or uveitis; Results after six months of treatment.

Long-term administration of Ibopamine hydrochloride eye drops restores and maintains intraocular pressure in patients with hypotony following vitreoretinal surgery for ablatio reinae, or uveitis.

Atomoxetine in children with pervasive developmental disorders.

Atomoxetine will be effective in reducing symptoms of inattention and overactivity in children and adolescents with ASD.

Neoadjuvant pre-radical prostatectomy gene therapy (HSV-tk gene transduction followed by Ganciclovir) in patients with poor prognostic indicators.

N/A

Protocol for treatment and research of acute lymphoblastic leukaemia of childhood
of the Dutch Childhood Oncology Group (SNWLK/DCOG ALL-9).

This reduced intensity protocol is instituted to: 1. Confirm the data obtained in the SNWLK-ALL-6 protocol for standard risk patients; 2. Offer significant improvement of cure rate in high risk patients, comparable to international childhood ALL…

Growth and development of children born after IVF.

Conditions during an IVF procedure might interfere with fetal growth and development and thereby permanently influencing the programming of organs and their function.

Radiation dose intensity study in breast cancer in young women: a randomized phase III trial of additional dose to the tumor bed.

10 Gy additional boost to the tumor bed will yield an increase in local control at 10 years from 88% to 93%, with still acceptable cosmesis.