186 resultaten
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
The effects of a brief compassion induction exercise will be compared to the effects of a neutral exercise. We hypothesize that a brief compassion induction in a sample of patients with PD will facilitate the choice of more adaptive emotion…
We hypothesised that this strategy could lead to a considerable and relevant change of prescribing behaviour in the desired direction.
A self help brochure will help people decrease their excessive worrying. and telephonic support will increase the effect.
At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
The implementation of the delirium part of the Vulnerable elderly project will improve when nurses have completed an e-learning tool regarding delirium care for elderly patients.
Continuous Passive Motion in the early post-operative periode after knee surgery is beneficiary for the rehabilation process in children with cerebral palsy.
The intention to change behavior is related to changes in multiple physiological variables. Thermal comfort and thermal sensation are related to these physiological parameters. Furthermore, the intention of behavior is related to changes in thermal…
1. Inhaltion of tobramycin containing aerosols using the INeb® in the TBM mode is less effective as inhalation of in the TIM mode; 2. The amount of deposition is correlated to the systemic Area Under the Curve of tobramycin after inhaltion of…
The percentage of curatively treatable metastatic disease after surgery for primary colorectal cancer can be increased by means of optimizing follow-up of colorectal carcinoma. Intensifying the follow-up by increasing frequency of CEA measurements…
1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…
The study of determinants of cardiovascular disease (CVD) is important because it provides insight in risks and opportunities to reduce the burden of CVD. A major gap in our current knowledge about CVD lies in the way we measure these determinants,…
At least 90% of the subjects, with 95% confidence, will tolerate the test formula.
B2-agonists can increase CFTR function and improve disease parameters in patients with CF with a residual CFTR function. Multiple patient-specific parameters are important for the amount of B2-agonist induced CFTR function, measurements in organoids…
The aim of this study is to investigate the effectiveness of a brief computer intervention to improve body satisfaction and self-esteem in a clinical population of adolescents with an eating disorder. We will examine whether the intervention is…
We hypothesize that there is no difference between the survival and follow of the uncemented and cemented ABG THA.
To evaluate the effects of a versatile web-based health game on cognition and compliance in Parkinson’s disease with mild cognitive impairment.
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…