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We hypothesize that age-related changes in hepatic and intestinal drug metabolism affect the pharmacokinetics of midazolam.
The use of progestins in combination with estrogen is associated with a reduced incidence of colorectal carcinoma (CRC)1,2. Also, incidental literature has reported a coincidence of the start of oral contraceptive agents with reduction in polyp…
A 10% point difference between the experimental groups and control group in MPV uptake is expected.
Test weighing using a double-check weighing method is precise in determining infant intake: in more than 90% of weighings test weighing will be within 5ml of the actual amount drunk
Well-being after root canal treatment with RISA irrigation. Frequency and intensity of postoperative pain.
For patients with stage III-IV irresectable melanoma who have at most 3 metastases, the tumor can be reduced in size by treating with dabrafenib and trametinib for 8 weeks. After this reduction, complete surgery of the tumor could be made possible.
Insomnia patients form a heterogeneous group, each phenotypes of insomnia will show different therapeutic demands.
Primary Objective To describe how patients experience the first eight weeks after shoulder arthroplasty, regarding pain and pain medication, shoulder function and quality of life. To determine the direct effect of patients' expectations on…
The TORCH screen is often requested by gynecologists, but there rarely is a clinical relevant outcome. Isn’t it better to reduce the test indications or the number of tested infections to make the test more cost effective and clinical relevant? And…
Childhood obesity is an important public health problem. Replacing Sugar Sweetened Beverages by the consumption of water and systematically increasing physical activity levels are promising health behavioral changes that may prevent childhood…
There is no reliable biological marker for the diagnosis of Acute Mountain Sickness (AMS), so AMS is presently assessed with questionnaires: the Lake Louise self-report score (LLSRS) and the abbreviated Environmental Symptoms Questionnaire (ESQc).…
The study will test the hypothesis that osimertinib treatment result a partial response in 30 % of patients.
Testing trials: 1. We expect to see a main effect of time on number a) of tests completed b) of persons who get tested c) of tests per person 2. We expect to see a main effect of letter condition. Specifically, we expect that the…
The primary endpoint of this study is to assess if myocardial strain and strain rate -measured with tissue Doppler and 2D speckle tracking- determined with TOE is comparable with cardiac strain and strain rate determined with TTE. Secondary…
In this single subject study we would like to determine whether parameter optimizing is feasible. Furthermore we want to investigate whether patients with urge symptoms have optimal benefit from different parameters than patients with non-…
Applying to the antibiotic checklist - based on generic quality indicators for the antibiotic treatment of bacterial infections in the hospital - will likely result into better patient care in terms of adequate treatment, duration of intensive care…
The objectives are firstly that Love is... promotes the healthy sexual development by increasing knowledge and positive attitudes towards sexuality. Secondly, characteristics of adolescents who do not improve from the general prevention program are…
To assess the effectiveness of the Xience stent compared to the CYPHER stent in the PCI treatment of all patients in the MCL during 2007- 2008. This study runs parallel with the XAMI study.